Chelation of cadmium without increased renal cadmium deposition

Journal Article · Thu Mar 01 00:00:00 EST 1984 · Environ. Health Perspect.; (United States)

DOI:https://doi.org/10.1289/ehp.8454243· OSTI ID:5975316

Cherian, M G

A number of chelating agents containing both carboxyl and thiol groups were able to mobilize and excrete Cd more easily in a short time (1/2 hr) after Cd exposure than longer times (24 hr), after MT synthesis. The renal deposition of Cd increased on BAL (2,3-dimercaptopropanol) treatment is a short time (1/2 hr) after Cd exposure. However, it was observed that if BAL was administered 24 hr after Cd exposure, it could mobilize Cd from hepatic MT and increase the biliary excretion of Cd without any increase in renal Cd concentration. Studies using a number of structurally related thiols (mono-, di- and trithiols) showed that the major structural requirement for in vivo chelation of Cd from intracellular MT were the vicinal thiol groups on an aliphatic chain, and lipophilicity. BAL was the most effective of all the compounds studied and it did not mobilize Cd to the kidney, when most of the intracellular Cd was bound to MT. Furthermore, a delayed treatment with BAL or DTPA (diethylenetriamine pentaacetic acid) after synthesis of MT resulted in an increase in fecal or urinary excretion of Cd in rat model experiment. The injection of DTPA in combination with BAL was more effective in decreasing the concentration of Cd and MT in liver and kidney from rats chronically exposed to Cd than injection of BAL alone. Since DTPA cannot enter the cell, it may be acting extracellularly in removing the Cd. The results of these studies suggest that the specific intracellular binding of Cd to MT is an important factor in protecting kidney, the critical organ, in the effective chelation of Cd by BAL.

• Research Organization: Univ. of Western Ontario, London, ON (Canada)
• OSTI ID: 5975316
• Journal Information: Environ. Health Perspect.; (United States), Vol. 54
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CADMIUM
BIOLOGICAL ACCUMULATION
METABOLISM
CHELATING AGENTS
BIOLOGICAL EFFECTS
METALLOTHIONEIN
BIOCHEMICAL REACTION KINETICS
BAL
BILIARY TRACT
CHEMICAL BONDS
DTPA
EXCRETION
EXPERIMENTAL DATA
KIDNEYS
LIVER
RATS
STRUCTURE-ACTIVITY RELATIONSHIPS
AMINO ACIDS
ANIMALS
BODY
CARBOXYLIC ACIDS
CLEARANCE
DATA
DIGESTIVE SYSTEM
DITHIOLS
DRUGS
ELEMENTS
GLANDS
INFORMATION
KINETICS
MAMMALS
METALLOPROTEINS
METALS
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PROTEINS
RADIOPROTECTIVE SUBSTANCES
REACTION KINETICS
REAGENTS
RODENTS
THIOLS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)