Effects of chelating agents on oral uptake and renal deposition and excretion of cadmium. [Mice]

Journal Article · Thu Mar 01 04:00:00 EST 1984 · Environ. Health Perspect.; (United States)

DOI:https://doi.org/10.1289/ehp.8454219· OSTI ID:5975198

Engstroem, B

The gastrointestinal absorption, transport, tissue deposition and excretion of cadmium was studied in adult male mice given a single oral LD/sub 50/ dose of /sup 109/Cd-labeled CdCl/sub 2/ alone or in combination with nitrilotriacetic acid (NTA), sodium tripolyphosphate (STPP) or ethylenediaminetetraacetic acid (EDTA). Blood, intestinal mucosa, liver and kidneys were analyzed for /sup 109/Cd at different times after exposure and the influence of the chelating agents on Cd binding to metallothionein and other tissue ligands was also studied. The effect of different chelating agents on acute cadmium toxicity and metabolism seemed to be due to changes in the stability of the administered chelate complexes, due to variation in pH and to the availability of metal binding ligands such as metallothionein in vivo. NTA, STPP and EDTA had no effect on the metabolism or toxicity of cadmium after long-term low dose oral exposure. 43 references, 4 tables, 9 figures.

• Research Organization: National Institute of Environmental Medicine, Stockholm, Sweden
• OSTI ID: 5975198
• Journal Information: Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 54; ISSN EVHPA
• Country of Publication: United States
• Language: English

Related Subjects

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
CADMIUM
CADMIUM 109
CADMIUM ISOTOPES
CARBOXYLIC ACIDS
CHELATING AGENTS
CHEMICAL ANALYSIS
CHEMICAL BONDS
CHRONIC EXPOSURE
CLEARANCE
DATA
DIGESTIVE SYSTEM
DISTRIBUTION
EDTA
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
EXCRETION
EXPERIMENTAL DATA
GASTROINTESTINAL TRACT
GLANDS
INFORMATION
INTERMEDIATE MASS NUCLEI
INTESTINES
ISOTOPES
KIDNEYS
KINETICS
LIVER
MAMMALS
MATERIALS
MEMBRANES
METABOLISM
METALLOPROTEINS
METALLOTHIONEIN
METALS
MICE
MUCOUS MEMBRANES
NTA
NUCLEI
NUMERICAL DATA
ORAL ADMINISTRATION
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PH VALUE
PROTEINS
RADIOISOTOPES
RATS
REACTION KINETICS
RODENTS
TISSUE DISTRIBUTION
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES