Some effects of high dietary levels of various salts of copper in broiler chickens

Conference · Tue Jan 01 04:00:00 EST 1974 · Trace Subst. Environ. Health; (United States)

OSTI ID:5973973

Norvell, M J; Thomas, M C; Goatcher, W D; Gable, D A; Calvert, C C

Day old female broiler chicks were housed in floor pens and fed a commercial broiler diet supplemented with graded levels (up to 720 ppM copper) of copper acetate, chloride, oxide or sulfate. At four and six weeks of age, broilers receiving the basal diet (containing 16 ppM Cu) and each high Cu supplemented treatment group were weighed and placed in individual metabolism cages. At six weeks of age, some of the birds continued to receive the same diets they had received previously and others were changed from the high Cu diets to the basal diet. All birds were individually weighed and sacrificed at eight weeks of age. Samples of liver, breast muscle, kidney, blood and excreta were analyzed for Cu by atomic absorption spectrophotometry. Samples of crop, duodenum, ileum, liver and pancreas were taken from all birds for histological observations. Parameters considered in these studies included histopathological observations, mortality, rates of growth, changes of the Cu content of various tissues and excreta (urine and feces). Calculations on the extents and rates of Cu depletion from birds receiving various sources of Cu were derived from these data. Data obtained in these trials indicate that except for copper oxide, growth was inversely proportional and tissue Cu residues were directly proportional to increasing levels of dietary Cu. Histological changes of the selected portions of the gastrointestinal tract as well as mortality were not affected. All affected parameters were statistically significant (P less than or equal to .05) at the high level of Cu supplementation. 9 references, 6 tables.

• Research Organization: Food and Drug Administration, Rockville, MD
• OSTI ID: 5973973
• Report Number(s): CONF-740696-
• Conference Information: Journal Name: Trace Subst. Environ. Health; (United States) Journal Volume: 8
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION SPECTROSCOPY
ANIMAL GROWTH
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BIRDS
BLOOD
BODY
BODY FLUIDS
CHICKENS
CLEARANCE
COMPARATIVE EVALUATIONS
COPPER
DIGESTIVE SYSTEM
DISTRIBUTION
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
ENDOCRINE GLANDS
EXCRETION
FECES
FOWL
GLANDS
GROWTH
INGESTION
INHIBITION
INTAKE
KIDNEYS
LIVER
MATERIALS
METALS
MUSCLES
ORGANS
PANCREAS
SPECTROSCOPY
TISSUE DISTRIBUTION
TRANSITION ELEMENTS
VERTEBRATES
WASTES