Planned preoperative radiation therapy vs. definitive radiotherapy for advanced laryngeal carcinoma

Journal Article · Mon Oct 01 00:00:00 EDT 1984 · Laryngoscope; (United States)

DOI:https://doi.org/10.1288/00005537-198410000-00017· OSTI ID:5973945

Kazem, I; van den Broek, P

In the period 1970-1980 inclusive, 191 patients with T3T4 laryngeal carcinoma (glottic: 63 and supraglottic: 128) received either definitive radiation therapy (RT) (60-65 Gy in 6-7 weeks) or planned preoperative radiation therapy (25 Gy in 5 equal daily fractions of 5 Gy) followed by laryngectomy with or without neck dissection (RT + S). Selection for RT vs. RT + S was based on medical operability and/or patient's refusal to undergo surgery. All patients are evaluable with minimum of 2 years observation. Crude 5 and 10-year survival probability for 32 patients with glottic localization who received RT is 55% and 38% vs. 65% and 65% respectively for 31 treated with RT + S. For 52 patients with supraglottic site who received RT, the 5 and 10-year survival is 44% and 44% vs. 82% and 60% for 76 patients treated with RT + S.

• Research Organization: Catholic Univ., Nijmegen, Netherlands
• OSTI ID: 5973945
• Journal Information: Laryngoscope; (United States), Vol. 94:10
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CARCINOMAS
RADIOTHERAPY
PATIENTS
SURVIVAL TIME
LARYNX
RADIATION DOSES
DISEASES
DOSES
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
RADIOLOGY
RESPIRATORY SYSTEM
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)