Advanced supraglottic carcinoma: a comparative study of sequential treatment policies

Journal Article · Mon Oct 01 04:00:00 EDT 1984 · Head Neck Surg.; (United States)

DOI:https://doi.org/10.1002/hed.2890070106· OSTI ID:5826860

Seiden, A M; Mantravadi, R P; Haas, R B; Applebaum, E L

Data from 131 consecutive patients with operable stage III or IV (American Joint Committee) supraglottic carcinoma were analyzed. Based on existing treatment policies at the time of presentation, patients received either preoperative radiation therapy (RT) (48 patients), surgery alone (42 patients), or postoperative RT (41 patients). Preoperative RT dose levels were either 2000 rad in five fractions (33 patients) or 5000 rad in 25 fractions (15 patients). Postoperative RT dosages were 5000 to 6000 rad in 6 to 6 1/2 weeks. Surgical procedures included either subtotal or total laryngectomy and radical neck dissection. Tumor control was achieved in 21 of 42 patients (50%) treated with surgery alone, 23 of 48 patients (48%) treated with preoperative RT, and 29 of 41 patients (71%) treated with postoperative RT (P . 0.005). The actuarial, recurrence-free survival at 5 years was 36% and 35%, respectively, in the surgery alone or preoperative RT groups as compared to 55% in postoperatively irradiated patients. The authors conclude that advanced but resectable supraglottic carcinomas may be best treated with surgery followed by RT, rather than with surgery alone or with combined preoperative RT and surgery.

• Research Organization: Univ. of Illinois, Chicago
• OSTI ID: 5826860
• Journal Information: Head Neck Surg.; (United States), Journal Name: Head Neck Surg.; (United States) Vol. 7:1; ISSN HNSUD
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
CARCINOMAS
COMPARATIVE EVALUATIONS
DISEASES
DOSES
FRACTIONATED IRRADIATION
IRRADIATION
LARYNX
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
PATIENTS
RADIATION DOSES
RADIOLOGY
RADIOTHERAPY
RESPIRATORY SYSTEM
SURGERY
SURVIVAL TIME
THERAPY