Superoxide release by neutrophils: synergistic effects of a phorbol ester and a calcium ionophore
Journal Article
·
· Biochem. Biophys. Res. Commun.; (United States)
Exposure to combined suboptimal concentrations of 4..beta..-phorbol 12-myristate 13-acetate and the calcium ionophore A23187 stimulates superoxide release from guinea pig neutrophils to rates ca. 3.5-fold greater than the sum of the rates elicited by each of the agents added separately. This effect was largely dependent upon the presence of calcium in the extracellular medium. The data are discussed in relation to recent reports concerning the interactions of phorbol-esters with cells and the mechanism of activation of superoxide release by neutrophils. 25 references, 1 figure, 2 tables.
- Research Organization:
- Harvard Medical School, Boston, MA
- OSTI ID:
- 5969971
- Journal Information:
- Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 122:2; ISSN BBRCA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH METALS
ANIMALS
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CALCIUM
CARCINOGENS
CHEMISTRY
CLEARANCE
ELEMENTS
ESTERS
GUINEA PIGS
LEUKOCYTES
MAMMALS
MATERIALS
METABOLIC ACTIVATION
METALS
NEUTROPHILS
ORGANIC COMPOUNDS
PHORBOL ESTERS
RADICALS
RODENTS
SUPEROXIDE RADICALS
SYNERGISM
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH METALS
ANIMALS
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CALCIUM
CARCINOGENS
CHEMISTRY
CLEARANCE
ELEMENTS
ESTERS
GUINEA PIGS
LEUKOCYTES
MAMMALS
MATERIALS
METABOLIC ACTIVATION
METALS
NEUTROPHILS
ORGANIC COMPOUNDS
PHORBOL ESTERS
RADICALS
RODENTS
SUPEROXIDE RADICALS
SYNERGISM
VERTEBRATES