Absorption and retention of uranium from drinking water by rats and rabbits
Journal Article
·
· Health Physics; (United States)
- Bureau of Radiation and Medical Devices, Department of National Health and Welfare, Ottawa, Ontario (Canada)
Uranium in the form of uranyl nitrate hexahydrate was administered in drinking water to Sprague-Dawley rats for periods of 28 and 91 d and New Zealand White rabbits for 91 d. The animals consumed food and water ad libitum. Subgroups of rabbits were followed for recovery periods of up to 91 d; 24-h collections of urine and feces were performed for some of the rabbits at various times during the exposure and recovery periods. At the end of the experiment, all animals were sacrificed and femur and kidney samples were analyzed for uranium residues. The results show that both rats and rabbits absorb about 0.06% of ingested uranium in the gastrointestinal (GI) tract. The distribution and retention of uranium in the skeleton and kidneys of rats are comparable to parameters reported for humans. The retention half-time in rabbit bone is substantially longer than for humans. The implications of extrapolating from animal data to effects on humans are discussed.
- OSTI ID:
- 5964762
- Journal Information:
- Health Physics; (United States), Journal Name: Health Physics; (United States) Vol. 62:1; ISSN 0017-9078; ISSN HLTPA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ACTINIDES
ANIMALS
BODY
DISTRIBUTION
DRINKING WATER
ELEMENTS
HYDROGEN COMPOUNDS
INTESTINAL ABSORPTION
KIDNEYS
MAMMALS
METALS
ORGANS
OXYGEN COMPOUNDS
POLLUTION
RABBITS
RADIONUCLIDE KINETICS
RATS
RETENTION
RODENTS
SKELETON
TISSUE DISTRIBUTION
UPTAKE
URANIUM
VERTEBRATES
WATER
WATER POLLUTION
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ACTINIDES
ANIMALS
BODY
DISTRIBUTION
DRINKING WATER
ELEMENTS
HYDROGEN COMPOUNDS
INTESTINAL ABSORPTION
KIDNEYS
MAMMALS
METALS
ORGANS
OXYGEN COMPOUNDS
POLLUTION
RABBITS
RADIONUCLIDE KINETICS
RATS
RETENTION
RODENTS
SKELETON
TISSUE DISTRIBUTION
UPTAKE
URANIUM
VERTEBRATES
WATER
WATER POLLUTION