Metabolism of radiohafnium in rats and hamsters: a possible analog of plutonium for metabolic studies

Journal Article · Mon Aug 01 04:00:00 EDT 1983 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576260· OSTI ID:5742041

Taylor, D M; Lehmann, M; Planas-Bohne, F; Seidel, A

The metabolism of radiohafnium (/sup 175/Hf + /sup 181/Hf) was studied in male Sprague-Dawley rats and Chinese hamsters for periods of up to 168 days. The results were compared with similar data for /sup 239/Pu in the same rat strain. In rats and hamsters the radiohafnium organ distribution was skeleton > skin > muscle > liver at about 7 days postinjection. Retention of radiohafnium and plutonium was similar in plasma and liver, as were the retention time observed for other organs: Absorption of radiohafnium from the gastrointestinal tract of rats was <0.05%. Biochemical studies showed that the radiohafnium was bound mainly to the iron-transport protein, transferrin, in blood plasma and in the liver cytosol of both the rat and the hamster, as has been observed also for plutonium. The metabolic behavior of radiohafnium mimics, to a large extent, that of plutonium, and it is suggested that radiohafnium can serve as a non-..cap alpha..-particle-emitting analog of plutonium for metabolic, biochemical, and selected human investigations.

• Research Organization: Kernforschungszentrum Karlsruhe, Germany
• OSTI ID: 5742041
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 95:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560172* -- Radiation Effects-- Nuclide Kinetics &amp; Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ACID PHOSPHATASE
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD PLASMA
BODY
BODY FLUIDS
CHELATING AGENTS
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ENZYMES
ESTERASES
EVEN-ODD NUCLEI
FUNCTIONS
GLANDS
HAFNIUM 175
HAFNIUM 181
HAFNIUM ISOTOPES
HAMSTERS
HEAVY NUCLEI
HYDROLASES
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
INTRAVENOUS INJECTION
IRON 59
IRON ISOTOPES
ISOTOPES
LIVER
MAMMALS
MATERIALS
MUSCLES
NUCLEI
ORGANS
PHOSPHATASES
PLUTONIUM 239
PLUTONIUM ISOTOPES
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RETENTION FUNCTIONS
RODENTS
SKELETON
SKIN
TISSUE DISTRIBUTION
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES