Chromosome abnormalities in Down's syndrome patients with acute leukemia

Journal Article · Tue Sep 01 04:00:00 EDT 1981 · Blood; (United States)

OSTI ID:5964019

Kaneko, Y ^[1]; Rowley, J D; Variakojis, D; Chilcote, R R; Moohr, J W; Patel, D

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1. Univ. of Chicago, IL

Chromosome and cytologic studies were performed on three Down's syndrome (DS) patients with acute nonlymphocytic leukemia (ANLL). All three patients had an aneuploid clone in their leukemic cells: 50,XX, +6, +19, +21, +22, 48,XX, +8, +21, and 47,XY, +8, -21, +dic(21;21)(p13;p11). Every patient appeared to have acute undifferentiated leukemia when the blast cells were examined with Wright-Giemsa stain; cytochemistry studies, however, showed that the leukemic blasts were in an early stage of myeloid differentation. The two patients with +8 had a preleukemic phase; the blast cells of the patient with an extra no. 19 and no. 22 could not be differentiated morphologically from those of the two patients with an extra no. 8. Our findings and a review of data on 40 other patients suggest that most DS children with ANLL have hyperdiploidy, which is usually related to gains of C, F, and/or G chromosomes.

• DOE Contract Number: AC02-80EV10360
• OSTI ID: 5964019
• Journal Information: Blood; (United States), Journal Name: Blood; (United States) Vol. 58:3; ISSN BLOOA
• Country of Publication: United States
• Language: English

Related Subjects

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550400 -- Genetics
550900* -- Pathology
59 BASIC BIOLOGICAL SCIENCES
BIOCHEMISTRY
BIOLOGY
CHEMISTRY
CHROMOSOMAL ABERRATIONS
CHROMOSOMES
CONGENITAL MALFORMATIONS
CYTOLOGY
DISEASES
DOWNS SYNDROME
GENETICS
GLOBULINS
HEMIC DISEASES
HEREDITARY DISEASES
IMMUNOGLOBULINS
KARYOTYPE
LEUKEMIA
MALFORMATIONS
MORPHOLOGY
MUTATIONS
NEOPLASMS
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
PATHOLOGY
PATIENTS
PROTEINS