Karyotypic abnormalities and clinical aspects of patients with multiple myeloma and related paraproteinemic disorders
Karyotypic abnormalities were detected in the malignant cells of 6 of 18 patients with multiple myeloma (MM). Six patients with benign monoclonal gammopathy, one with amyloidosis of immunoglobulin origin, and two with Waldenstroem's macroglobulinemia had normal karyotypes. All six MM patients with aneuploidy were in a group of 10 patients in an accelerated or relapse phase of their disease and four had high serum paraprotein levels when their abnormal karyotypes were detected. Five of the 6 MM patients with aneuploidy had received prior chemotherapy. Aneuploidy was not observed in 8 stable MM patients. Abnormalities of chromosome 14 were present in all 6 patients. A translocation between Nos. 11 and 14 was found in aneuploid cells of 2 patients who had plasma cell leukemia (PCL). A deletion of chromosome 6 was detected in 2 MM patients and a pericentric inversion of No. 6 was seen in the patient with PCL. Three of 4 MM patients had a nonrandom loss of one chromosome 8. Two other MM patients developed acute nonlymphocytic leukemia (ANLL) after the diagnosis of MM. Marrow cells of one patient showed a 5q- chromosome and a constitutional translocation involving Nos. 13 and 14 during the preleukemic stage; during the leukemic phase, the karyotype evolved to 50 chromosomes including extra chromosomes 1, 6, 8, 10, and 21 and a missing 7, in addition to the originally detected 5q- and the 13/14 translocation.The peripheral blood from the other patient was hypodiploid, with a missing chromosome 7 and a translocation between 3q and 9p. These patterns of chromosome change resemble those of ANLL rather than MM and are similar to the changes seen in ANLL after treated malignant lymphoma.
- Research Organization:
- Univ. of Chicago, IL
- OSTI ID:
- 5299756
- Journal Information:
- Cancer; (United States), Journal Name: Cancer; (United States) Vol. 44:2; ISSN CANCA
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
ANEUPLOIDY
ANIMAL CELLS
BIOLOGICAL MATERIALS
BLOOD
BODY FLUIDS
CHEMOTHERAPY
CHROMOSOMAL ABERRATIONS
CHROMOSOMES
DISEASES
HEMIC DISEASES
KARYOTYPE
LEUKEMIA
LYMPHOMAS
LYMPHOSARCOMAS
MATERIALS
MUTATIONS
NEOPLASMS
PATHOLOGY
PATIENTS
PLOIDY
SARCOMAS
THERAPY
TUMOR CELLS