Tachykinin receptors mediating airway marcomolecular secretion

Journal Article · Tue Jan 01 04:00:00 EST 1991 · Life Sciences; (USA)

DOI:https://doi.org/10.1016/0024-3205(91)90120-Z· OSTI ID:5962917

Gentry, S E ^[1]

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1. Univ. of Pittsburgh School of Medicine, PA (USA)

Three tachykinin receptor types, termed NK1, NK2, and NK3, can be distinguished by the relative potency of various peptides in eliciting tissue responses. Airway macromolecular secretion is stimulated by the tachykinin substance P (SP). The purposes of this study were to determine the tachykinin receptor subtype responsible for this stimulation, and to examine the possible involvement of other neurotransmitters in mediating this effect. Ferret tracheal explants maintained in organ culture were labeled with {sup 3}H-glucosamine, a precursor of high molecular weight glycoconjugates (HMWG) which are released by airway secretory cells. Secretion of labeled HMWG then was determined in the absence and presence of the tachykinins SP, neurokinin A (NKA), neurokinin B (NKB), physalaemin (PHY), and eledoisin (ELE). To evaluate the possible contribution of other mediators, tachykinin stimulation was examined in the presence of several receptor blockers.

• OSTI ID: 5962917
• Journal Information: Life Sciences; (USA), Journal Name: Life Sciences; (USA) Vol. 48:17; ISSN 0024-3205; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINES
ANIMALS
BIOCHEMICAL REACTION KINETICS
CARBOHYDRATES
GLUCOSAMINE
GLYCOPROTEINS
HEXOSAMINES
HEXOSES
HYDROGEN COMPOUNDS
ISOTOPE APPLICATIONS
KINETICS
KININS
MAMMALS
MEMBRANE PROTEINS
MONOSACCHARIDES
ORGANIC COMPOUNDS
PEPTIDES
POLYPEPTIDES
PROTEINS
REACTION KINETICS
RECEPTORS
RESPIRATORY SYSTEM
SACCHARIDES
SECRETION
TRACER TECHNIQUES
TRACHEA
TRITIUM COMPOUNDS
VERTEBRATES