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Pulsed Er:YAG- and 308 nm UV-excimer laser: an in vitro and in vivo study of skin-ablative effects

Journal Article · · Lasers Surg. Med.; (United States)
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Using a pulsed XeCl excimer laser (308 nm) and a pulsed Er:YAG laser (2,940 nm), we investigated skin ablation as a function of pulse number, radiant energy, and repetition rate. In vitro analysis of lesions performed in freshly excised human skin were consistent with in vivo results obtained from experiments on pig skin. Pulsed 308 nm laser radiation caused considerable nonspecific thermal tissue injury followed by an inflammatory reaction and impaired healing of lesions in vivo. These findings were especially pronounced with higher repetition rates, which would be required for efficient destruction of larger lesions. On the other hand, the 2.94 microns Er:YAG laser radiation produced clean and precise lesions with only minimal adjacent injury. In vivo skin ablation caused intraoperative bleeding with deeper penetration. The Er:YAG laser offers a promising surgical tool for careful removal of superficial epidermal lesions, if higher repetition rates, and an appropriate laser beam delivery system are available for clinical use.

Research Organization:
Institut fuer Lasertechnologien in der Medizin an der Universitaet Ulm (Germany, F.R.)
OSTI ID:
5962899
Journal Information:
Lasers Surg. Med.; (United States), Journal Name: Lasers Surg. Med.; (United States) Vol. 9:2; ISSN LSMED
Country of Publication:
United States
Language:
English

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Related Subjects

550600 -- Medicine
560400* -- Other Environmental Pollutant Effects
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
DOMESTIC ANIMALS
ELECTROMAGNETIC RADIATION
EXCIMER LASERS
GAS LASERS
IN VITRO
IN VIVO
LASER RADIATION
LASERS
MAMMALS
MAN
MEDICINE
ORGANS
PRIMATES
RADIATIONS
SENSITIVITY
SKIN
SURGERY
SWINE
VERTEBRATES