Prevention of HLA alloimmunization: Role of leukocyte depletion and UV-B irradiation
Journal Article
·
· Yale Journal of Biology and Medicine; (USA)
OSTI ID:5956523
- Yale Univ. School of Medicine, New Haven, CT (USA)
HLA alloimmunization is a major cause of the platelet refractory state. The stimulus for HLA alloimmunization is believed to derive from incompatibility between the recipient's lymphocytes and the passenger donor lymphocytes contained in transfused red cells or platelet concentrates. Two techniques to prevent post-transfusion HLA alloimmunization include filtration, which physically removes the donor lymphocytes, and UV-B irradiation, which renders the donor leukocytes biologically inactive. The role of these two techniques in the prevention of HLA alloimmunization is the focus of this review.42 references.
- OSTI ID:
- 5956523
- Journal Information:
- Yale Journal of Biology and Medicine; (USA), Journal Name: Yale Journal of Biology and Medicine; (USA) Vol. 63:5; ISSN YJBMA; ISSN 0044-0086
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIGEN-ANTIBODY REACTIONS
ANTIGENS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DOCUMENT TYPES
DOGS
ELECTROMAGNETIC RADIATION
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MAN
MATERIALS
PRIMATES
RADIATION EFFECTS
RADIATIONS
REVIEWS
SOMATIC CELLS
THERAPY
TRANSFUSIONS
ULTRAVIOLET RADIATION
VERTEBRATES
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIGEN-ANTIBODY REACTIONS
ANTIGENS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DOCUMENT TYPES
DOGS
ELECTROMAGNETIC RADIATION
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MAN
MATERIALS
PRIMATES
RADIATION EFFECTS
RADIATIONS
REVIEWS
SOMATIC CELLS
THERAPY
TRANSFUSIONS
ULTRAVIOLET RADIATION
VERTEBRATES