Tc-99m red blood cells for the study of rapid hemolytic processes associated with heterologous blood transfusions

Journal Article · Mon Oct 01 04:00:00 EDT 1984 · Clin. Nucl. Med.; (United States)

DOI:https://doi.org/10.1097/00003072-198410000-00005· OSTI ID:5948345

Benedetto, A R; Harrison, C R; Blumhardt, R; Trow, L L

Chromium-51 labeled erythrocytes (Cr-51 RBC) are suitable for the study of hematologic disorders which involve relatively slow destruction of circulating erythrocytes, taking several days to several weeks. However, Cr-51 RBC are not suitable for investigating rapid hemolytic processes which occur within a matter of a few hours due to the variable and unpredictable elution of Cr-51 from the erythrocytes during the first 24 hours or so. Imaging, which could be useful in identifying organ systems involved in the hemolytic process, cannot be performed with Cr-51 RBC because of the high dose commitment caused by the low yield of gamma rays from Cr-51 (2). A method of labeling RBC with Tc-99m, which results in a radiopharmaceutical that combines the excellent dosimetric and imaging qualities of Tc-99m with an extremely stable bond between the Tc-99m and the RBC, is reported. The successful application of this technique in providing red cell support for a cancer patient with an unusual history of intravascular hemolytic transfusion reactions is also reported.

• Research Organization: Univ. of Texas Health Science Center, San Antonio
• OSTI ID: 5948345
• Journal Information: Clin. Nucl. Med.; (United States), Journal Name: Clin. Nucl. Med.; (United States) Vol. 9:10; ISSN CNMED
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD GROUPS
BODY FLUIDS
CHROMIUM 51
CHROMIUM ISOTOPES
DISEASES
DRUGS
DYNAMIC FUNCTION STUDIES
ELECTRON CAPTURE RADIOISOTOPES
ERYTHROCYTES
EVEN-ODD NUCLEI
HEMOLYSIS
HOURS LIVING RADIOISOTOPES
IMMUNE REACTIONS
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LYSIS
MATERIALS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
PATHOLOGICAL CHANGES
PATIENTS
RADIOISOTOPES
RADIOPHARMACEUTICALS
TECHNETIUM 99
TECHNETIUM ISOTOPES
THERAPY
TRACER TECHNIQUES
TRANSFUSIONS
YEARS LIVING RADIOISOTOPES