Labeling of blood cells with /sup 99m/Tc

Conference · Tue Jan 01 04:00:00 EST 1974

OSTI ID:4327933

Eckelman, W C; Smith, T D; Richards, P

Erythrocytes, leukocytes, and tumor cells were labeled with /sup 99m/Tc to take advantage of the ideal physical properties of /sup 99m/Tc. Clinical studies indicate that labeled erythrocytes can be used to obtain improved vascular and splenic imaging as well as reliable red cell volumes. The erythrocytes have been labeled with and without the use of an added reducing agent. Two methods of adding the reducing agent stannous chloride have been proposed which differ in the order of addition of the stannous ion and the pertechnetate. The preliminary reports of labeling of leukocytes and tumor cells offer hope that further development will result in truly specific radiopharmaceuticals. (auth)

• Research Organization: Brookhaven National Lab., Upton, N.Y. (USA)
• NSA Number: NSA-29-021249
• OSTI ID: 4327933
• Report Number(s): BNL--18497; CONF-740203--3
• Country of Publication: United States
• Language: English

Related Subjects

*ERYTHROCYTES-- LABELLING
*LEUKOCYTES-- LABELLING
*TECHNETIUM 99-- RADIOCHEMISTRY
*TUMOR CELLS-- LABELLING
CHEMICAL PREPARATION
IN VITRO
ISOMERIC NUCLEI
N40120 --Chemistry--Analytical & Separations Chemistry--Chemical & Spectral Procedures
N48830* --Life Sciences--New Tracer Techniques--Other
NUCLEAR MEDICINE
RADIOISOTOPE SCANNING
RADIOPHARMACEUTICALS
UPTAKE