Evaluation of labeling procedures and in vivo stability of /sup 99m/Tc-red blood cells
Journal Article
·
· J. Nucl. Med., v. 17, no. 2, pp. 133-136
OSTI ID:4059308
Stable labeling of red blood cells (RBCs) with /sup 99m/Tc, in yields of about 66 percent, was achieved by using stannous chloride as a reducing agent. In a study of 12 patients, the stability of technetium-labeled RBCs in the circulation varied significantly among individuals, but the average biologic half- life of the labeled cells was 16.8 hr. Although the labeling yield was lower when the labeling was carried out without EDTA with the addition of stannous chloride after the pertechnetate, this sequence appears to be the best for labeling RBCs for use in obtaining images of the blood pool or the cardiovascular system because of the increased viability of the RBCs. (auth)
- Research Organization:
- Univ. of Chicago
- NSA Number:
- NSA-33-023654
- OSTI ID:
- 4059308
- Journal Information:
- J. Nucl. Med., v. 17, no. 2, pp. 133-136, Journal Name: J. Nucl. Med., v. 17, no. 2, pp. 133-136; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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OSTI ID:6854794
Related Subjects
*CARDIOVASCULAR SYSTEM-- SCINTISCANNING
*ERYTHROCYTES-- LABELLING
*SCINTISCANNING-- TECHNETIUM 99
*TECHNETIUM 99-- RADIOCHEMISTRY
550601* --Biomedical Sciences
Basic Studies--Medicine-- Unsealed Radionuclides in Diagnostics
ISOMERIC NUCLEI
N40400 --Chemistry--Radiochemistry & Nuclear Chemistry
N48830* --Life Sciences--New Tracer Techniques--Other
TIN CHLORIDES
*ERYTHROCYTES-- LABELLING
*SCINTISCANNING-- TECHNETIUM 99
*TECHNETIUM 99-- RADIOCHEMISTRY
550601* --Biomedical Sciences
Basic Studies--Medicine-- Unsealed Radionuclides in Diagnostics
ISOMERIC NUCLEI
N40400 --Chemistry--Radiochemistry & Nuclear Chemistry
N48830* --Life Sciences--New Tracer Techniques--Other
TIN CHLORIDES