Ozone inactivation of human alpha 1-proteinase inhibitor
Journal Article
·
· Am. Rev. Respir. Dis.; (United States)
OSTI ID:5940252
Ozone decreased the trypsin, chymotrypsin, and elastase inhibitory activities of human alpha 1-proteinase inhibitor both in plasma and in solutions of the pure inhibitor. The total loss of porcine elastase inhibitory activity required 18 mol of ozone/mol of pure alpha 1-PI and approximately 850 mol of ozone/mol of alpha 1-PI in plasma. A corresponding loss of the ability to inhibit human leukocyte elastase was observed. Inactivated alpha 1-PI contains four residues of methionine sulfoxide, in addition to oxidized tryosine and tryptophan. Electrophoretic analysis demonstrated that the ozone-inactivated alpha 1-PI did not form normal complexes with serine proteinases. These findings suggest that the inhalation of ozone could inactivate alpha 1-PI on the airspace side of the lung to create a localized alpha 1-PI deficiency, which might contribute to the development of emphysema.
- OSTI ID:
- 5940252
- Journal Information:
- Am. Rev. Respir. Dis.; (United States), Journal Name: Am. Rev. Respir. Dis.; (United States) Vol. 121:6; ISSN ARRDA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
552000 -- Public Health
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
99 GENERAL AND MISCELLANEOUS
AMINO ACIDS
AZOLES
BIOLOGICAL EFFECTS
BODY
CARBOXYLIC ACIDS
CHEMICAL ANALYSIS
CHEMICAL REACTIONS
DISEASES
EMPHYSEMA
ENZYME ACTIVITY
ENZYMES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INDOLES
INHALATION
INHIBITION
INTAKE
LUNGS
METABOLISM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OZONE
PYRROLES
QUANTITATIVE CHEMICAL ANALYSIS
REDOX REACTIONS
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SENSITIVITY
TOXICITY
TRYPTOPHAN
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
99 GENERAL AND MISCELLANEOUS
AMINO ACIDS
AZOLES
BIOLOGICAL EFFECTS
BODY
CARBOXYLIC ACIDS
CHEMICAL ANALYSIS
CHEMICAL REACTIONS
DISEASES
EMPHYSEMA
ENZYME ACTIVITY
ENZYMES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INDOLES
INHALATION
INHIBITION
INTAKE
LUNGS
METABOLISM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OZONE
PYRROLES
QUANTITATIVE CHEMICAL ANALYSIS
REDOX REACTIONS
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SENSITIVITY
TOXICITY
TRYPTOPHAN