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Improved imaging of metastatic melanoma with high dose 9. 2. 27 In-111 monoclonal antibody

Conference · · J. Nucl. Med.; (United States)
OSTI ID:5939394
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In-111 monoclonal antibody (MoAb) 9.2.27, a IgG2a, directed against a melanoma-associated antigen was administered in escalating doses (1-100 mg) to 9 patients (pts) with metastatic melanoma. This product (5 pts) or mixtures with 50 mg (3 pts) or 100 mg (1 pt) of unlabeled 9.2.27 was infused over 2 hr and serial scanning was performed from 2 hr to 6d. In an attempt to block nonspecific organ uptake 2 pts received 7.5 grams preinfusion of human gamma globulin (gamimmune). 2 of 5 pts receiving 1 mg had 2 of 8 known sites which were scan positive. In addition to tumor uptake, liver spleen and bone marrow uptake was prominent. Pts receiving greater than or equal to 50 mg had less ''non-specific'' organ uptake, and more prolonged plasma retention with 52% versus 14% in plasma at 24 hr. Pre-infusion of gamimmune had no effect on biodistribution. Predominant excretion was renal with 3% per day after the first 24 hours. No toxicity was observed. An antimouse immune response was seen in 1 of 4 pts tested. This data shows significant dose-dependent differences in biodistribution of In-111 9.2.27 with improved tumor detection at the higher dose levels.

Research Organization:
Medicine Dept., NIH, Bethesda, MD
OSTI ID:
5939394
Report Number(s):
CONF-850611-
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 26:5; ISSN JNMEA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BLOOD CHEMISTRY
CARBOXYLIC ACIDS
CHELATING AGENTS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
DISTRIBUTION
DOSIMETRY
DRUGS
DTPA
ELECTRON CAPTURE RADIOISOTOPES
GLOBULINS
GLOBULINS-GAMMA
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LABELLING
MELANOMAS
METASTASES
MINUTES LIVING RADIOISOTOPES
MONOCLONAL ANTIBODIES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
PATIENTS
PROTEINS
RADIOIMMUNOSCINTIGRAPHY
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
RADIOPROTECTIVE SUBSTANCES
SCINTISCANNING
TISSUE DISTRIBUTION
UPTAKE
USES