An evaluation of /sup 99m/Tc-TMP as a myocardial imaging agent
Based on the recent report (JNM 25:P15,'84) that cationic /sup 99m/Tc-TMP localized well in animal myocardium, the authors evaluated it for possible clinical use. It was prepared by heating dry /sup 99m/TcO/sub 4/ with 50 mg of TMP in <0.5 ml of methanol or DMSO at 98/sup 0/C for 30'. This reaction also produced 6-10% of an anionic complex impurity (RPTLC, KC/sub 18/F plate, 2% dimethyl phosphite in methanol). This impurity and unreacted TMP were removed by passing the complex through 3x1cm BIOSIL A column and washing with saline. Carrier free /sup 99m/Tc-TMP was eluted with 0.5 ml ethanol, diluted with saline and injected intravenously to rats, rabbits, cats, dogs and rhesus monkey for gamma camera imaging. Excellent myocardial localization was seen in all animals. The quantitative myocardial uptake of /sup 99m/Tc-TMP in rats was comparable to that of /sup 201/Tl. A normal male volunteer was injected with 6.6 mCi of /sup 99m/Tc TMP and gamma camera images were obtained. By 24 hrs, 16% of the injected dose was recovered in the urine. The /sup 99m/Tc-TMP in plasma was not protein bound as determined by gel chromatography and electrophoresis. There seems to be a wide species difference between man and animals in the pharmacokinetics and localization of /sup 99m/Tc-TMP.
- Research Organization:
- Upstate Medical Center, Syracuse, NY
- OSTI ID:
- 5938898
- Report Number(s):
- CONF-850611-
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 26:5; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BODY
CARDIOVASCULAR SYSTEM
CATS
CHEMICAL PREPARATION
CLEARANCE
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISTRIBUTION
DMSO
DOGS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVALUATION
EXCRETION
HEART
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTRAVENOUS INJECTION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KINETICS
LABELLED COMPOUNDS
LABELLING
MACACUS
MAMMALS
MAN
MONKEYS
MUSCLES
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PRIMATES
RABBITS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
RATS
REACTION KINETICS
RENAL CLEARANCE
RODENTS
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
SULFOXIDES
SYNTHESIS
TECHNETIUM 99
TECHNETIUM ISOTOPES
THALLIUM 201
THALLIUM ISOTOPES
TISSUE DISTRIBUTION
UPTAKE
USES
VERTEBRATES
YEARS LIVING RADIOISOTOPES