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Small charged macromolecules for assessing glomerular disease

Conference · · J. Nucl. Med.; (United States)
OSTI ID:5938545
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Only about 50% of patients with biopsy-proven glomerular disease have shown significant depression of inulin or creatinine clearance. Previously discussed was a greater difference in clearance of unlabeled charged dextrans than with inulin or neutral dextrans between rats with glomerular damage and normal controls. The charged macromolecules reflected the early loss of the normal anionic charge of the glomerulus in disease. The authors have explored this principle for radionuclide studies. After limited coupling with the cyclic diahydride of DTPA, the In-111 labeled aminated dextran was injected IV simultaneously with Tc-99m DTPA in Sprague-Dawley rats. Glomerular damage was induced with IV puromycin aminonucleoside (5 mg/100g body wt) 9 days previously, for comparison with normal controls. Plasma clearance was determined from multiple blood samples over 2 hours. Urine and organs were assayed after sacrifice 2 hours after injection. The results are presented in this paper. If these results prove valid for man, radiolabeled charged small macromolecules should improve the assessment of spontaneous glomerulopathies compared to conventional ''glomerular'' agents.

Research Organization:
Upstate Medical Center, Syracuse, NY
OSTI ID:
5938545
Report Number(s):
CONF-850611-
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 26:5; ISSN JNMEA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD SUBSTITUTES
BODY
CARBOHYDRATES
CARBOXYLIC ACIDS
CHELATING AGENTS
CHEMICAL PREPARATION
CLEARANCE
CREATININE
DEXTRAN
DIAGNOSIS
DIAGNOSTIC USES
DISEASES
DRUGS
DTPA
DYNAMIC FUNCTION STUDIES
EXCRETION
FUNCTIONS
GLOMERULI
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
HORMONES
HOURS LIVING RADIOISOTOPES
IMIDAZOLES
IMINES
INSULIN
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LABELLING
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PEPTIDE HORMONES
POLYSACCHARIDES
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
RADIOPROTECTIVE SUBSTANCES
RENAL CLEARANCE
RETENTION FUNCTIONS
SACCHARIDES
SYNTHESIS
TECHNETIUM 99
TECHNETIUM ISOTOPES
UROGENITAL SYSTEM DISEASES
USES
YEARS LIVING RADIOISOTOPES