Inhibitory effects of xylitol on gastric emptying and food intake

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:5938515

Shafer, R B; Levine, A S; Marlette, J M; Morley, J E

The authors have previously shown, using a 99m-Tc scrambled egg meal, that pentose sugars (i.e. xylose and arabinose) markedly prolong gastric emptying. Others have reported that slowing of gastric emptying may decrease appetite and thus decrease food intake. In the present study, the authors utilized the effects of xylitol (an FDA-approved pentose sugar) on gastric emptying to study the correlation between gastric emptying and food intake. Initially, gastric emptying was measured in human volunteers utilizing a standardized 99m-Tc-scrambled egg meal washed with 50 cc tap water. Results demonstrated a significant reduction in food intake (892 +- 65 kcal with water vs 654 +- 26 kcal following the ingestion of 25 gm xylitol (p<0.05). We conclude that the effect of pentose sugars in prolonging gastric emptying directly influences food intake and contributes to early satiety. The data suggest a role of xylitol as an essentially non-caloric food additive potentially important in diet control.

• Research Organization: V.A. Medical Center, Minneapolis, MN
• OSTI ID: 5938515
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
ARABINOSE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CARBOHYDRATES
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DIET
DIGESTION
DIGESTIVE SYSTEM
DYNAMIC FUNCTION STUDIES
GASTROINTESTINAL TRACT
HOURS LIVING RADIOISOTOPES
HYDROGEN COMPOUNDS
INGESTION
INHIBITION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MONOSACCHARIDES
NUCLEI
ODD-EVEN NUCLEI
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PENTOSES
RADIOISOTOPE SCANNING
RADIOISOTOPES
SACCHARIDES
SCINTISCANNING
STOMACH
TECHNETIUM 99
TECHNETIUM ISOTOPES
USES
WATER
XYLOSE
YEARS LIVING RADIOISOTOPES