Organization and evolution of the rat tyrosine hydroxylase gene

Journal Article · Tue Aug 11 04:00:00 EDT 1987 · Biochemistry; (United States)

DOI:https://doi.org/10.1021/bi00390a046· OSTI ID:5934418

Brown, E R; Coker, III, G T; O'Malley, K L

This report describes the organization of the rat tyrosine hydroxylase (TH) gene and compares its structure with the human phenylalanine hydroxylase gene. Both genes are single copy and contain 13 exons separated by 12 introns. Remarkably, the positions of 10 out 12 intron/exon boundaries are identical for the two genes. These results support the idea that these hydroxylases genes are members of a gene family which has a common evolutionary origin. The authors predict that this ancestral gene would have encoded exons similar to those of TH prior to evolutionary drift to other members of this gene family.

• Research Organization: Washington Univ. Medical School, St. Louis, MO
• OSTI ID: 5934418
• Journal Information: Biochemistry; (United States), Journal Name: Biochemistry; (United States) Vol. 26:16; ISSN BICHA
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EVOLUTION
DAYS LIVING RADIOISOTOPES
DNA SEQUENCING
ENZYMES
GENES
HYDROXYLASES
ISOTOPES
LIGHT NUCLEI
MAMMALS
MAN
NUCLEI
ODD-ODD NUCLEI
OXIDOREDUCTASES
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
PRIMATES
RADIOISOTOPES
RATS
RODENTS
STRUCTURAL CHEMICAL ANALYSIS
TYROSINASE
VERTEBRATES