16,16-Dimethyl prostaglandin E2 increases survival in mice following irradiation
16,16-Dimethyl prostaglandin E2(DiPGE2), a stable analog of PGE2, increases the LD 50/30 survival in CD2F1 male mice when given prior to ionizing radiation. Subcutaneous administration of 40 microgram of DiPGE2 30 min prior to /sup 60/Co gamma irradiation extends the LD 50/30 from 9.39 Gy in the control animals to 16.14 Gy in DiPGE2 treated, with a dose-reduction factor of 1.72p95% confidence limits: 1.62, 1.82. The degree of protection is dependent on both the time of administration and the dose of the prostaglandin. Ten micrograms administered 5 min prior to receiving a lethal dose of 10 Gy provides 90% survival but only 10% survival if administered 30 min prior to irradiation. Experiments to determine the in vivo concentration of DiPGE2 in organs post injection show increased levels over time, but these are not correlated with protection. At 30 min after injection, as much as 80% of the DiPGE2 present in the spleen and plasma is unmetabolized. These results suggest that the protection results from the physiologic action of DiPGE2 rather than direct in vivo detoxification of radicals.
- Research Organization:
- Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
- OSTI ID:
- 5934212
- Report Number(s):
- AD-A-183500/8/XAB; AFRRI-SR-87-21
- Resource Relation:
- Other Information: Pub. in Radiation Research, Vol. 109, 440-448(1987)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
LETHAL RADIATION DOSE
RADIOPROTECTIVE SUBSTANCES
EFFICIENCY
BIOLOGICAL RADIATION EFFECTS
DETOXIFICATION
IRRADIATION
METHYL RADICALS
MICE
PROSTAGLANDINS
SPLEEN
ALKYL RADICALS
ANIMALS
BIOLOGICAL EFFECTS
BODY
DOSES
DRUGS
LETHAL DOSES
MAMMALS
ORGANS
RADIATION DOSES
RADIATION EFFECTS
RADICALS
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals