Protection of mice against mixed fission neutron-gamma (n: gamma = 1:1) irradiation by WR-2721, 16,16-dimethyl PGE2, and the combination of both agents

Journal Article · Thu Sep 01 04:00:00 EDT 1988 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3577309· OSTI ID:6865234

Steel, L K; Walden, Jr, T L; Hughes, H N; Jackson, W.E. 3d.

The survival of mice after whole-body exposure to a modified fission neutron-gamma field (n: gamma = 1:1) was used to examine radiation protection by WR-2721, 16,16-dimethyl PGE2(DiPGE2), and the combination of both agents. Administration of WR-2721 (453 mg/kg) increased the LD50/30 from 5.24 to 7.17 Gy (DMF = 1.37), whereas pretreatment with DiPGE2 (1.6 mg/kg) increased the LD50/30 to 5.77 Gy (dose modification factor (DMF) = 1.10). The combination of 453 mg/kg WR-2721 and 0.4 mg/kg DiPGE2 resulted in an LD50/30 of 7.33 Gy, yielding a DMF of 1.39. However, no significant difference in protection was obtained with the combination of the two agents compared to that seen with WR-2721 alone.

• Research Organization: Department Armed Forces Radiobiology Research Institute, Bethesda, MD (USA)
• OSTI ID: 6865234
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 115:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BARYONS
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
EXTERNAL IRRADIATION
FERMIONS
FISSION NEUTRONS
GAMMA RADIATION
HADRONS
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MICE
NEUTRONS
NUCLEONS
RADIATION PROTECTION
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RODENTS
SURVIVAL CURVES
VERTEBRATES
WHOLE-BODY IRRADIATION