Dose and time relationships of the radioprotector WR-2721 on locomotor activity in mice

Technical Report · Thu Jan 01 04:00:00 EST 1987

OSTI ID:5934202

Landauer, M R; Davis, H D; Dominitz, J A; Weiss, J F

The effects of the radioprotector S-2-(3-aminopropylamino)ethylphosphorothioic acid (WR-2721) on locomotor activity were evaluated in CD2F1 male mice. Separate groups of animals (N=10/group) received an IP injection of vehicle, 25, 50, 100, 200, or 400 mg/kg of WR-2721 immediately before testing. Horizontal and vertical activity were measured using a Digiscan automated animal-activity monitor. The latency to onset and duration of action of each dose of the radioprotector were recorded. For both behavioral measures, a significant reduction was observed in activity at doses of 200 and 400 mg/kg. A dose of 200 mg/kg had a 12- to 14-min latency to onset and significantly reduced behavioral activity for 3 hr. Mice injected with 400 mg/kg exhibited locomotor deficits within 8-10 min and were affected for up to 9 hr. The ED50 for horizontal and vertical activities at 1 hr postinjection were determined to be 271 and 105 mg/kg, respectively. The results demonstrate that significant reductions in locomotor activity are exhibited at doses of 200mg/kg or more and that vertical activity was more sensitive to the disruptive effects of WR-2721 than was horizontal activity.

• Research Organization: Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
• OSTI ID: 5934202
• Report Number(s): AD-A-183581/8/XAB; AFRRI-SR-87-14
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BEHAVIOR
BIOLOGICAL EFFECTS
CHEMICAL REACTIONS
DRUGS
INJECTION
INTAKE
LABORATORY ANIMALS
MAMMALS
MICE
RADIOPROTECTIVE SUBSTANCES
REDUCTION
RODENTS
VERTEBRATES