Dose and time relationships of the radioprotector WR-2721 on locomotor activity in mice
Journal Article
·
· Pharmacol., Biochem. Behav.; (United States)
The effects of the radioprotector S-2-(3-aminopropylamino)ethylphosphorothioic acid (WR-2721) on locomotor activity were evaluated in CD2F1 male mice. Separate groups of animals (N = 10/group) received an IP injection of vehicle, 25, 50, 100, 200, or 400 mg/kg of WR-2721 immediately before testing. Horizontal and vertical activity were measured using a Digiscan automated animal activity monitor. The latency to onset and duration of action of each dose of the radioprotector were recorded. For both behavioral measures, a significant reduction was observed in activity at doses of 200 and 400 mg/kg. A dose of 200 mg/kg had a 12- to 14-min latency to onset and significantly reduced behavioral activity for 3 hr. Mice injected with 400 mg/kg exhibited locomotor deficits within 8-10 min and were affected for up to 9 hr. The ED50 for horizontal and vertical activities at 1 hr postinjection were determined to be 271 and 105 mg/kg, respectively. The results demonstrate that significant reductions in locomotor activity are exhibited at doses of 200 mg/kg or more and that vertical activity was more sensitive to the disruptive effects of WR-2721 than was horizontal activity.
- Research Organization:
- Armed Forces Radiobiology Research Institute, Bethesda, MD
- OSTI ID:
- 5621819
- Journal Information:
- Pharmacol., Biochem. Behav.; (United States), Journal Name: Pharmacol., Biochem. Behav.; (United States) Vol. 27:3; ISSN PBBHA
- Country of Publication:
- United States
- Language:
- English
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