Differential expression of three glutamate receptor genes in developing rat brain: An in situ hybridization study

Journal Article · Wed May 15 04:00:00 EDT 1991 · Proceedings of the National Academy of Sciences of the United States of America; (United States)

DOI:https://doi.org/10.1073/pnas.88.10.4157· OSTI ID:5934071

Pellegrini-Giampietro, D E; Bennett, M V.L.; Zukin, R S ^[1]

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1. Albert Einstein Coll. of Medicine, Bronx, NY (United States)

Non-N-methyl-D-aspartate glutamate receptors (GluRs) are encoded by a gene family, known members of which are designated Glu-1,-2,-3,-4, and -5. The present study examined the developmental pattern of GluR-1,-2, and -3 gene expression in rat brain. In situ hybridization revealed different spatial patterns throughout the brain for the cognate mRNAs at all ages examined, as well as different temporal patterns during development, In the adult all three mRNAs were expressed prominently in the pyramidal and granule layers of the hippocampus and in the Purkinje cell layer of the cerebellum, where detailed differences were apparent at the cellular level. The finding of differential developmental regulation of the GluR-1,-2, and -3 genes indicates that the receptors they encode may have different influences on synaptic plasticity, neuronal survival, and susceptibility to excitatory amino acid toxicity.

• OSTI ID: 5934071
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (United States), Journal Name: Proceedings of the National Academy of Sciences of the United States of America; (United States) Vol. 88:10; ISSN 0027-8424; ISSN PNASA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
ADULTS
AGE GROUPS
AMINO ACIDS
ANIMALS
AUTORADIOGRAPHY
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BRAIN
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
DNA HYBRIDIZATION
EVEN-ODD NUCLEI
GENE REGULATION
GLUTAMIC ACID
HYBRIDIZATION
ISOTOPES
LIGHT NUCLEI
MAMMALS
MEMBRANE PROTEINS
MESSENGER-RNA
NERVOUS SYSTEM
NUCLEI
NUCLEIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPES
RATS
RECEPTORS
RNA
RODENTS
SULFUR 35
SULFUR ISOTOPES
TRANSCRIPTION
VERTEBRATES