Physico-chemical methods for the study of polycyclic aromatic hydrocarbon carcinogen-DNA interactions: Progress report, March 1, 1985 to August 31, 1987

Technical Report · Mon Aug 31 00:00:00 EDT 1987

OSTI ID:5933091

Geacintov, N E

Linear dichroism was used to study the conformations of polycyclic aromatic carcinogen-DNA adducts and non-covalent complexes, as well as for following the kinetics of the interactions of the highly reactive metabolites of these carcinogens with DNA in aqueous solutions. We have also begun to investigate the fluorescence properties of carcinogen-DNA adducts. The results of these studies on the base-sequence selectivities and base-sequence specificities of the interactions of polycyclic aromatic hydrocarbon diol epoxides with nucleic acids, have stimulated the developments of models of reaction mechanisms and biological activity/carcinogen-DNA adduct structure relationships. 18 refs., 4 figs., 1 tab.

• Research Organization: New York Univ., NY (USA)
• DOE Contract Number: AC02-78EV04959
• OSTI ID: 5933091
• Report Number(s): DOE/EV/04959-9; ON: DE88000899
• Resource Relation: Other Information: Portions of this document are illegible in microfiche products
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
DNA
CONFORMATIONAL CHANGES
DICHROISM
DNA ADDUCTS
ABSORPTION SPECTROSCOPY
BENZOPYRENE
BIOPHYSICS
POLYCYCLIC AROMATIC HYDROCARBONS
ADDUCTS
AROMATICS
CONDENSED AROMATICS
HYDROCARBONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
SPECTROSCOPY
560300* - Chemicals Metabolism & Toxicology
550200 - Biochemistry