Vaccination of bovines against Schistosomiasis japonica with highly irradiated schistosomula in China
Vaccination of Chinese bovines (cattle and buffaloes) against Schistosomiasis japonica with 36 kR gamma-irradiated schistosomula was done for laboratory challenge and for field trials in China. Altogether, 61 bovines were used. All experimental animals were vaccinated 2-3 times with 10,000 irradiated schistosomula per time. For the laboratory challenge, all experimental and control cattle were challenged with 500 normal cercariae and each buffalo, with 2,000 cercariae. The laboratory-challenged bovines were killed after 54-57 days of challenge; the bovines for the field trial in the lightly endemic area, after 5 months in the field; and the bovines for the field trial in the heavily endemic area, after 58-63 days. When the animals were killed, the number of mature worms in the vaccinated (experimental) and non-vaccinated (control) animals was recorded and the percentage of worm reduction in each group was calculated. The first group, consisting of three vaccinated and three non-vaccinated cattle, was given a laboratory challenge; the worm reduction was 71.6%. The second group, consisting of two vaccinated and three non-vaccinated buffaloes, was also given a laboratory challenge; the worm reduction was 74.4%. The third group, consisting of seven vaccinated and eight non-vaccinated buffaloes, was utilized in a field trial in a lightly endemic area; the worm reduction was 75.6%. The fourth group, consisting of eight vaccinated and nine non-vaccinated cattle, and the fifth group, consisting of nine vaccinated and nine non-vaccinated buffaloes, were pastured in a heavily endemic area. The worm reduction was 65.1% in the fourth group and 75.7% in the fifth group.
- Research Organization:
- Univ. of Iowa, Iowa City
- OSTI ID:
- 5931931
- Journal Information:
- Am. J. Trop. Med. Hyg.; (United States), Vol. 33:5
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BUFFALO
INOCULATION
CATTLE
SCHISTOSOMA
BIOLOGICAL RADIATION EFFECTS
SCHISTOSOMIASIS
PATHOGENESIS
CHINA
GAMMA RADIATION
VACCINES
ANIMALS
ASIA
BIOLOGICAL EFFECTS
DISEASES
DOMESTIC ANIMALS
ELECTROMAGNETIC RADIATION
HELMINTHS
INFECTIOUS DISEASES
IONIZING RADIATIONS
MAMMALS
PARASITIC DISEASES
PLATYHELMINTHS
RADIATION EFFECTS
RADIATIONS
RUMINANTS
TREMATODES
VERTEBRATES
550600* - Medicine
560134 - Radiation Effects on Microorganisms- Vaccine Preparation & Other Applications- (-1987)