Effects of ozone on the respiratory health, allergic sensitization, and cellular immune system in children

Journal Article · Fri Nov 01 00:00:00 EST 1991 · American Review of Respiratory Disease (New York); (United States)

DOI:https://doi.org/10.1164/ajrccm/144.5.1075· OSTI ID:5929028

Zwick, H; Popp, W; Wagner, C; Reiser, K; Schmoeger, J B; Boeck, A H; Herkner, K; Radunsky, K ^[1]

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1. Pulmonary Department, Krankenhaus Lainz, Vienna (Austria)

To investigate the lasting effects of high ozone concentrations under environmental conditions, we examined the respiratory health, pulmonary function, bronchial hyperresponsiveness to methacholine, allergic sensitization, and lymphocyte subpopulations of 10- to 14-yr-old children. A total of 218 children recruited from an area with high ozone concentrations (Group A) were tested against 281 children coming from an area with low ozone concentrations (Group B). As to subjective complaints, categorized as 'usually cough with or without phlegm,' 'breathlessness,' and 'susceptibility to chest colds,' there was no difference between the two groups. The lung function parameters were similar, but in Group A subjects' bronchial hyperresponsiveness occurred more frequently and was found to be more severe than in Group B (29.4 versus 19.9%, p less than 0.02; PD20 2,100 {plus minus} 87 versus 2,350 {plus minus} 58 micrograms, p less than 0.05). In both groups the number of children who had been suffering from allergic diseases and sensitization to aeroallergens, found by means of the skin test, was the same. Comparison of the total IgE levels showed no difference at all between the two groups. As far as the white blood cells are concerned, the total and differential cell count was the same, whereas lymphocyte subpopulations showed readily recognizable changes.

• OSTI ID: 5929028
• Journal Information: American Review of Respiratory Disease (New York); (United States), Vol. 144:5; ISSN 0003-0805
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
OZONE
TOXICITY
RESPIRATORY SYSTEM
SENSITIVITY
AIR POLLUTION
ALLERGY
CHILDREN
ENVIRONMENTAL EXPOSURE
IMMUNOGLOBULINS
INHALATION
LYMPHOCYTES
RESPIRATION
AGE GROUPS
ANIMAL CELLS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
GLOBULINS
INTAKE
LEUKOCYTES
MATERIALS
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
POLLUTION
PROTEINS
SOMATIC CELLS
560300* - Chemicals Metabolism & Toxicology