Analytical Chemistry Division annual progress report for period ending December 31, 1991

Technical Report · Wed Jan 01 04:00:00 EST 1992

DOI:https://doi.org/10.2172/5927657· OSTI ID:5927657

The following sentences highlight some of the technical activities carried out during 1991. They illustrate the diversity of programs and technical work performed within the Analytical Chemistry Division. Our neutron activation analysis laboratory at HFIR was placed into operation during 1991. We have combined inductively coupled plasma mass spectrometry (ICP/MS) with a preparation procedure developed at the Argonne National Laboratory to measure ultra-trace levels of U, Pu, Np, and Am in body fluids, primarily urine. Much progress has been made over the last year in the interfacing of an rf-powered glow discharge source to a double-focusing mass spectrometer. Preliminary experiments using electrospray ionization combined with ion trap mass spectrometry show much promise for the analysis of metals in solution. A secondary ion microprobe has been constructed that permits determination of the distribution of organic compounds less than a monolayer thick on samples as large as 1 cm diameter. Fourier transform mass spectrometry has been demonstrated to be a highly effective tool for the detailed characterization of biopolymers, especially normal and modified oligonucleotides. Much has been accomplished in understanding the fundamentals of quadrupole ion trap mass spectrometry. Work with ITMS instrumentation has led to the development of rapid methods for the detection of trace organics in environmental and physiological samples. A new type of time-of-flight mass spectrometer was designed for use with our positron ionization experiments. Fundamental research on chromatography at high concentrations and on gas-solid adsorption has continued. The preparation of a monograph on the chemistry of environmental tobacco smoke was completed this year.

• Research Organization: Oak Ridge National Lab., TN (United States)
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 5927657
• Report Number(s): ORNL--6701; ON: DE92007804
• Country of Publication: United States
• Language: English

Related Subjects

400100* -- Analytical & Separations Chemistry
CHEMICAL ANALYSIS
CHEMICAL VAPOR DEPOSITION
CHROMATOGRAPHY
FOURIER TRANSFORM SPECTROMETERS
ION-MOLECULE COLLISIONS
MASS SPECTROSCOPY
NEUTRON ACTIVATION ANALYSIS
OPTICAL SPECTROMETERS
PROGRESS REPORT
RESEARCH PROGRAMS
TIME-OF-FLIGHT MASS SPECTROMETERS
TOBACCO SMOKES