Reevaluation of the dermal bioavailability of 2,3,7,8-TCDD in soil

Journal Article · · Hazardous Waste and Hazardous Materials; (USA)

DOI:https://doi.org/10.1089/hwm.1989.6.231· OSTI ID:5927361

Kissel, J C; McAvoy, D R ^[1]

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1. Indiana Univ., Bloomington (USA)

An assessment of risks associated with dioxin-contaminated soil, primarily attributable to Centers for Disease Control (CDC) personnel, has been criticized as too conservative for both residential and industrial locations. In analysis of risks at industrial locations, where the childhood oral ingestion pathway may be neglected, adequate quantification of the dermal exposure pathway is particularly important. Reexamination of the experiments on which CDC assumptions regarding dermal absorption efficiency were based indicates that CDC's dermal risk assessment is not conservative. Results generated using a fugacity-based dermal exposure model incorporated in a physiologically based pharmacokinetic model are presented. Dermal bioavailabilities well in excess of that assumed in the CDC assessment are predicted.

• OSTI ID: 5927361
• Journal Information: Hazardous Waste and Hazardous Materials; (USA), Journal Name: Hazardous Waste and Hazardous Materials; (USA) Vol. 6:3; ISSN 0882-5696; ISSN HWHME
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
540220* -- Environment
Terrestrial-- Chemicals Monitoring & Transport-- (1990-)
560300 -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
BIOLOGICAL AVAILABILITY
CONTAMINATION
DIOXIN
HETEROCYCLIC COMPOUNDS
LAND POLLUTION
MATHEMATICAL MODELS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
POLLUTION
RISK ASSESSMENT
SKIN ABSORPTION
SOILS
UPTAKE