Effects of chain length and tellurium position on the myocardial uptake of Te-123m fatty acids

Journal Article · Sun Nov 01 00:00:00 EST 1981 · J. Nucl. Med.; (United States)

OSTI ID:5926422

Knapp, F F ^[1]; Ambrose, K R; Callahan, A P; Ferren, L A; Grigsby, R A; Irgolic, K J

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1. Oak Ridge National Lab., TN

A series of Te-123m-labeled fatty acids has been synthesized and studied in rats. In the series of compounds studied, the position of the T-123m heteroatom was not as important as the total chain length, which dramatically affected the heart uptake. Five minutes after injection, significant heart uptake (1.7-2.3% of injected dose) was observed for agents with C/sub 15/, C/sub 17/ and C/sub 21/ chain lengths, in which Te-123m replaced a methylene group in either the 6, 9, 11 or 17 positions, and the heart-to-blood ratios were high. An important observation was the prolonged retention of radioactivity for at least one hour after injection. In contrast, agents with shorter C/sub 13/ chain lengths, with Te-123m in either the 6 or the 9 position, exhibited only low heart uptake (0.1-0.3% of injected dose).

• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 5926422
• Journal Information: J. Nucl. Med.; (United States), Vol. 22:11
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
CARDIOVASCULAR DISEASES
DIAGNOSIS
RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
CARBOXYLIC ACIDS
MYOCARDIUM
RATS
TELLURIUM 123
UPTAKE
ANIMALS
BODY
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
EVEN-ODD NUCLEI
HEART
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MUSCLES
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RODENTS
STABLE ISOTOPES
SYNTHESIS
TELLURIUM ISOTOPES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
400702 - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials