Effects of chain length and tellurium position on the myocardial uptake of Te-123m fatty acids

Journal Article · Sat Oct 31 23:00:00 EST 1981 · J. Nucl. Med.; (United States)

OSTI ID:5926422

Knapp, F F ^[1]; Ambrose, K R; Callahan, A P; Ferren, L A; Grigsby, R A; Irgolic, K J

---

1. Oak Ridge National Lab., TN

A series of Te-123m-labeled fatty acids has been synthesized and studied in rats. In the series of compounds studied, the position of the T-123m heteroatom was not as important as the total chain length, which dramatically affected the heart uptake. Five minutes after injection, significant heart uptake (1.7-2.3% of injected dose) was observed for agents with C/sub 15/, C/sub 17/ and C/sub 21/ chain lengths, in which Te-123m replaced a methylene group in either the 6, 9, 11 or 17 positions, and the heart-to-blood ratios were high. An important observation was the prolonged retention of radioactivity for at least one hour after injection. In contrast, agents with shorter C/sub 13/ chain lengths, with Te-123m in either the 6 or the 9 position, exhibited only low heart uptake (0.1-0.3% of injected dose).

• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 5926422
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 22:11; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702 -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHEMICAL PREPARATION
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DISEASES
DRUGS
EVEN-ODD NUCLEI
HEART
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MUSCLES
MYOCARDIUM
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RADIOPHARMACEUTICALS
RATS
RODENTS
STABLE ISOTOPES
SYNTHESIS
TELLURIUM 123
TELLURIUM ISOTOPES
UPTAKE
VERTEBRATES