Immunologic effects of whole-body ultraviolet (uv) irradiation
Journal Article
·
· Cell. Immunol.; (United States)
The daily exposure of a mouse to ultraviolet (uv) radiation causes a selective depletion of Ia-bearing adherent cells in that animal's spleen. This depletion manifests itself in functional deficiencies in the presentation of protein antigens and haptens to T cells. The present studies demonstrate a defect in splenic adherent cells (SAC) from uv-irradiated mice resulting in defective alloantigen presentation. We show that unfractionated splenocytes and SAC from uv-irradiated mice show decreased stimulatory activity in allogeneic MLR. We then utilize this phenomenon induced by uv radiation to characterize the stimulator cell in the M locus (Mls) determinant-driven MLR. We show that the stimulator cell in Mls determinant-driven MLR is an adherent cell and demonstrate that this stimulator cell bears Ia determinants by showing the whole spleen cells and SAC from mice treated with uv radiation are inefficient stimulators of the Mls determinant-driven MLR. The importance of the Ia determinant on the stimulator cells in Mls determinant-driven MLR is corroborated by the demonstration that a monoclonal antibody directed at this determinant fully blocks the Mls determinant-driven MLR. The significance of these studies to the problem of alloreactions in vivo is discussed.
- Research Organization:
- Harvard Medical School, Boston, MA
- OSTI ID:
- 5922381
- Journal Information:
- Cell. Immunol.; (United States), Journal Name: Cell. Immunol.; (United States) Vol. 63:2; ISSN CLIMB
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550300 -- Cytology
560114* -- Radiation Effects on Biochemicals-- In Animals-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIBODIES
ANTIGENS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CELL PROLIFERATION
CONNECTIVE TISSUE CELLS
DATA
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
IMMUNE REACTIONS
INFORMATION
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
NUMERICAL DATA
ORGANS
RADIATIONS
RODENTS
SOMATIC CELLS
SPLEEN
ULTRAVIOLET RADIATION
VERTEBRATES
560114* -- Radiation Effects on Biochemicals-- In Animals-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIBODIES
ANTIGENS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CELL PROLIFERATION
CONNECTIVE TISSUE CELLS
DATA
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
IMMUNE REACTIONS
INFORMATION
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
NUMERICAL DATA
ORGANS
RADIATIONS
RODENTS
SOMATIC CELLS
SPLEEN
ULTRAVIOLET RADIATION
VERTEBRATES