Role of complement in porphyrin-induced photosensitivity
Journal Article
·
· J. Invest. Dermatol.; (United States)
Addition of porphyrins to sera of guinea pigs in vitro, followed by irradiation with 405 nm light, resulted in dose-dependent inhibitions of hemolytic activity of complement. With guinea pig as an animal model, we also found that systemically administered porphyrins, followed by irradiation with 405 nm light, resulted in dose-dependent inhibition of CH50 in vivo. The erythrocytes from porphyrin-treated guinea pigs showed an increased susceptibility to hemolysis induced by 405 nm irradiation in vitro. Clinical changes in these animals were limited to light-exposed areas and consisted of erythema, crusting, and delayed growth of hair. Histologically, dermal edema, dilation of blood vessels, and infiltration of mononuclear and polymorphonuclear cells were observed. Guinea pigs irradiated with ultraviolet-B developed erythema, but had no alteration of their complement profiles. It is suggested that complement products may play a specific role in the pathogenesis of the cutaneous lesions of some porphyrias.
- OSTI ID:
- 5920336
- Journal Information:
- J. Invest. Dermatol.; (United States), Journal Name: J. Invest. Dermatol.; (United States) Vol. 76:1; ISSN JIDEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200 -- Biochemistry
551000 -- Physiological Systems
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOXYLIC ACIDS
COMPARATIVE EVALUATIONS
DOSE-RESPONSE RELATIONSHIPS
EDEMA
ELECTROMAGNETIC RADIATION
ERYTHEMA
ERYTHROCYTES
GUINEA PIGS
HEMATOPORPHYRINS
HEMOLYSIS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HISTOLOGY
LYSIS
MAMMALS
MATERIALS
METABOLISM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOLOGICAL CHANGES
PIGMENTS
PORPHYRINS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RODENTS
SYMPTOMS
ULTRAVIOLET RADIATION
VERTEBRATES
551000 -- Physiological Systems
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOXYLIC ACIDS
COMPARATIVE EVALUATIONS
DOSE-RESPONSE RELATIONSHIPS
EDEMA
ELECTROMAGNETIC RADIATION
ERYTHEMA
ERYTHROCYTES
GUINEA PIGS
HEMATOPORPHYRINS
HEMOLYSIS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HISTOLOGY
LYSIS
MAMMALS
MATERIALS
METABOLISM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOLOGICAL CHANGES
PIGMENTS
PORPHYRINS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RODENTS
SYMPTOMS
ULTRAVIOLET RADIATION
VERTEBRATES