Power burst facility/boron neutron capture therapy program for cancer treatment. [Borocaptate sodium]

Technical Report · Thu Nov 01 04:00:00 EST 1990

OSTI ID:5916558

Dorn, III, R V

Highlights of the Power Burst Facility/Boron Neutron Capture Therapy (PBF/BNCT) Program in November, 1990 are described. One of our major projects is support of technological development. In this area, progress has been seen in gross boron analysis of biological samples, higher purity borocaptate sodium (BSH), planning of experiments to investigate BSH biochemistry and oxidation products, bidding out for an ion microscope to investigate subcellular distribution of boron, and reduction of the gamma field in the irradiation room due to addition of lithiated polyethylene shielding. No progress was made on noninvasive boron quantitation, because the MRI system used is being upgraded, and the boron MR software must be rewritten. Brandy'' Hoff, a canine patient in the Large Animal Model studies, passed her one year physical and neurological exam. Three of the last four dogs treated for spontaneous brain tumors are doing well. Researchers at the University of Utah are planning human pharmacokinetic studies of BSH. BSH and BSS uptake in exemptions of terminal glioblastoma patients will be investigated. Layout and planning of tasks to begin PBF/BNCT Program reactor modifications have been initiated. The final design review for the bismuth reflector core partition sheet and lower orifice plate was completed on November 20, 1990. Agreements with DOE-ID relating to expenditure of the $13M for the PBF/BNCT Program have been reached. A review of the program by the National Academy of Science was requested by Admiral Watkins and took place in Washington, DC on November 5, 1990. This progress report also contains a summary of the 1990 accomplishments within the melanoma project. 2 figs. (MHB)

• Research Organization: EG and G Idaho, Inc., Idaho Falls, ID (USA)
• Sponsoring Organization: DOE; USDOE, Washington, DC (USA)
• DOE Contract Number: AC07-76ID01570
• OSTI ID: 5916558
• Report Number(s): EGG-BNCT-8777-Vol.4-No.11; ON: DE91010066
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BIOLOGICAL LOCALIZATION
BODY
BORON COMPOUNDS
BRAIN
CENTRAL NERVOUS SYSTEM
DIAGNOSTIC TECHNIQUES
DISEASES
DOCUMENT TYPES
DOGS
EXPERIMENT PLANNING
GLIOMAS
IDAHO NATIONAL ENGINEERING LABORATORY
MAMMALS
MANAGEMENT
MEDICINE
MELANOMAS
METABOLITES
MOCKUP
MODIFICATIONS
NATIONAL ORGANIZATIONS
NEOPLASMS
NERVOUS SYSTEM
NEUTRON CAPTURE THERAPY
NEUTRON THERAPY
NMR IMAGING
NUCLEAR MEDICINE
ORGANS
PBF REACTOR
PERSONNEL
PHANTOMS
PHARMACOLOGY
PLANNING
PROGRAM MANAGEMENT
PROGRESS REPORT
PULSED REACTORS
RADIOLOGY
RADIOTHERAPY
REACTORS
STRUCTURAL MODELS
TANK TYPE REACTORS
THERAPEUTIC USES
THERAPY
TRAINING
US DOE
US ERDA
US ORGANIZATIONS
USES
VERTEBRATES