Cellular morphometry of the bronchi of human and dog lungs
One hundred and thirty-one bronchial samples from 62 patients have been dissected by generation from fixed surgical lung specimens obtained after the removal of pathological lesions. Complete patient records including occupational and smoking histories, as well as possible exposure to radon, are obtained. In addition, one hundred and sixty-two mongol dog bronchi dissected from different lobes of 23 dog lungs have also been similarly prepared. Ninety-four human samples have been completely processed for electron microscopy and have yielded 994 electron micrographs of which 532 have been entered into the Computerized Stereological Analysis System (COSAS) and been used for the measurement of the distances of basal and mucous cell nuclei to the epithelial free surface. Similarly 240 micrographs of dog epithelium from 31 bronchial samples have been entered into COSAS. We have, using the COSAS planimetry program, established data bases which describe the volume density and nuclear numbers per electron micrograph for 5 cell types of the human bronchial epithelial lining of men and women, as well as smokers, non-smokers and ex-smokers and similar parameters for the epithelial cell types of dog bronchi. The data are being used to develop weighting factors for dosimetry and radon risk analysis. 26 refs., 7 figs., 4 tabs.
- Research Organization:
- New York Univ., NY (USA). Dept. of Cell Biology
- Sponsoring Organization:
- USDOE; USDOE, Washington, DC (USA)
- DOE Contract Number:
- FG02-88ER60656
- OSTI ID:
- 5915854
- Report Number(s):
- DOE/ER/60656-4; ON: DE91010939; TRN: 91-014303
- Country of Publication:
- United States
- Language:
- English
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Cellular morphometry of the bronchi of human and dog lungs. Progress report, April 1, 1991--October 1, 1991
Cellular morphometry of the bronchi of human and dog lungs
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