Radiation sterilization and its place in a series of drug sterilization methods

Journal Article · Wed May 01 04:00:00 EDT 1985 · High Energy Chem. (Engl. Transl.); (United States)

OSTI ID:5906561

Osipov, V B; Tal'roze, V L; Trofimov, V I

The authors base this work on the results of a survey in which they discussed the theoretical and applied problems involved in the use of ionizing radiation for the production of sterile medicinal preparations, showing that drugs can be irradiated under conditions permitting high reliability of sterilization without significant change in the physicochemical and biological properties of the preparation. Here the authors compare the basic indices of the process of using radiation treatment in pharmaceutical production and the characteristics of other sterilization techniques used in industry to establish the feasibility of an extensive introduction of radiation methods. Since the sterilization and partial decontamination techniques used in practice against microorganisms differ significantly, the question is applied to each problem separately.

• Research Organization: Institute of Chemical Physics, Academy of Sciences of the USSR
• OSTI ID: 5906561
• Journal Information: High Energy Chem. (Engl. Transl.); (United States), Journal Name: High Energy Chem. (Engl. Transl.); (United States) Vol. 19:4; ISSN HIECA
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400600 -- Radiation Chemistry
560130* -- Radiation Effects on Microorganisms
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CHEMISTRY
DRUGS
FEASIBILITY STUDIES
IONIZING RADIATIONS
IRRADIATION
MICROORGANISMS
RADIATION CHEMISTRY
RADIATION EFFECTS
RADIATIONS
RADIOSTERILIZATION
RELIABILITY
STERILIZATION