Prostaglandin synthesis is increased in selenium supplemented human mesangial cells despite suppression of phospholipase A2 - activity

Journal Article · Tue Jan 01 04:00:00 EST 1991 · Life Sciences; (United States)

DOI:https://doi.org/10.1016/0024-3205(91)90173-9· OSTI ID:5905562

Hampel, G; Reinke, M; Hren, J ^[1]

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1. Univ. of Erlangen-Nuernberg (West Germany)

Antioxidants play an important role in the regulation of phospholipid hydrolysis and arachidonate metabolism. Supplementation of cultured human mesangial cells with selenium resulted in suppression of phospholipase A2 - activity and significantly increased production of three major prostaglandins. However, prostacyclin synthesis benefits most from selenium supplementation, suggesting that there is a specific action of selenium-dependent glutathione peroxidase on this pathway. Like in endothelial cells, production of platelet activating factor is significantly inhibited by selenium supplementation.

• OSTI ID: 5905562
• Journal Information: Life Sciences; (United States), Journal Name: Life Sciences; (United States) Vol. 49:12; ISSN 0024-3205; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL PATHWAYS
BIOSYNTHESIS
CARBOXYLESTERASES
CELL CULTURES
ELEMENTS
ENZYME ACTIVITY
ENZYMES
ESTERASES
HYDROLASES
INHIBITION
LIPASES
MAMMALS
MAN
ORGANIC COMPOUNDS
PRIMATES
PROSTAGLANDINS
PROTEINS
SELENIUM
SEMIMETALS
SYNTHESIS
VERTEBRATES