Investigation of varicella-zoster virus infection of lymphocytes by in situ hybridization

Journal Article · Mon May 01 00:00:00 EDT 1989 · J. Virol.; (United States)

OSTI ID:5902565

Koropchak, C M; Solem, S M; Diaz, P S; Arvin, A M

Peripheral blood mononuclear cells harboring viral gene sequences were detected during primary varicella-zoster virus (VZV) infection of the human host and the strain 2 guinea pig by in situ hybridization with a /sup 3/H-labeled VZV DNA probe. Activated T lymphocytes were permissive for VZV infection at low frequency in vitro.

• Research Organization: Stanford Univ. School of Medicine, CA (USA)
• OSTI ID: 5902565
• Journal Information: J. Virol.; (United States), Vol. 63:5
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
LYMPHOCYTES
CELL PROLIFERATION
VIRAL DISEASES
PATHOGENESIS
VIRUSES
INFECTIVITY
AMINO ACID SEQUENCE
DNA HYBRIDIZATION
GUINEA PIGS
MAN
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
HYBRIDIZATION
INFECTIOUS DISEASES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LEUKOCYTES
MAMMALS
MATERIALS
MICROORGANISMS
MOLECULAR STRUCTURE
PARASITES
PRIMATES
RODENTS
SOMATIC CELLS
VERTEBRATES
550901* - Pathology- Tracer Techniques