Long-term survival of murine allogeneic bone marrow chimeras: effect of anti-lymphocyte serum and bone marrow dose
Journal Article
·
· J. Immunol.; (United States)
OSTI ID:5892798
Graft-vs-host disease (GVHD) and failure of donor stem cells to engraft permanently are two major obstacles to successful bone marrow transplantation. The effect of a single large dose of anti-lymphocyte serum (ALS) on mice receiving various numbers of H-2 incompatible bone marrow cells was evaluated. Most animals receiving lethal total body irradiation (TBI) and allogeneic marrow died within 45 days due to GVHD. Mice that were given ALS 6 to 24 h before TBI and bone marrow 24 h after irradiation survived in good health for more than 200 days. These cell preparations caused lethal GVHD in third party mice indicating that the lack of alloreactivity was specific to the strain in which the unresponsiveness was originally induced.
- OSTI ID:
- 5892798
- Journal Information:
- J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 126:2; ISSN JOIMA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550300 -- Cytology
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BONE MARROW CELLS
CHIMERAS
CONNECTIVE TISSUE CELLS
DOSE-RESPONSE RELATIONSHIPS
EXTERNAL IRRADIATION
GRAFT-HOST REACTION
GRAFTS
IMMUNE SERUMS
IMMUNOSUPPRESSION
IRRADIATION
LETHAL IRRADIATION
MAMMALS
MICE
MOSAICISM
RADIATION CHIMERAS
RADIOINDUCTION
RODENTS
SOMATIC CELLS
STEM CELLS
TRANSPLANTS
VERTEBRATES
WHOLE-BODY IRRADIATION
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BONE MARROW CELLS
CHIMERAS
CONNECTIVE TISSUE CELLS
DOSE-RESPONSE RELATIONSHIPS
EXTERNAL IRRADIATION
GRAFT-HOST REACTION
GRAFTS
IMMUNE SERUMS
IMMUNOSUPPRESSION
IRRADIATION
LETHAL IRRADIATION
MAMMALS
MICE
MOSAICISM
RADIATION CHIMERAS
RADIOINDUCTION
RODENTS
SOMATIC CELLS
STEM CELLS
TRANSPLANTS
VERTEBRATES
WHOLE-BODY IRRADIATION