Metal-isonitrile adducts for preparing radionuclide complexes for labelling and imaging agents
A method is described for preparing a coordination complex of an isonitrile ligand and a radioactive metal selected from the class consisting of radioactive isotopes of Tc, Ru, Co, Pt, Fe, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Pd, Nb and Ta. The method comprises preparing a soluble metal adduct of the isonitrile ligand by admixing the ligand with a salt of a displaceable metal having a complete d-electron shell selected from the class consisting of Zn, Ga, Cd, In, Sn, Hg, Tl, Pb and Bi to form a soluble metal-isonitrile salt, and admixing the metal isonitrile salt with a salt comprising the radioactive metal in a suitable solvent to displace the displaceable metal with the radioactive metal thereby forming the coordination complex.
- Assignee:
- President and Fellows of Harvard College and Massachusetts Institute of Technology, Cambridge, MA
- Patent Number(s):
- US 4707544
- OSTI ID:
- 5889877
- Country of Publication:
- United States
- Language:
- English
Similar Records
Isonitrile radionuclide complexes for labelling and imaging agents
Isonitrile radionuclide complexes for labelling and imaging agents
Related Subjects
400201* -- Chemical & Physicochemical Properties
ADDUCTS
BISMUTH COMPLEXES
CADMIUM COMPLEXES
CARBONIC ACID DERIVATIVES
CHEMICAL COMPOSITION
CHEMICAL PREPARATION
CHROMIUM ISOTOPES
COBALT ISOTOPES
COMPLEXES
GALLIUM ISOTOPES
IMAGE PROCESSING
INDIUM COMPLEXES
IRIDIUM ISOTOPES
IRON ISOTOPES
ISONITRILES
ISOTOPES
LABELLED COMPOUNDS
LEAD COMPLEXES
LIGANDS
MANGANESE ISOTOPES
MERCURY COMPLEXES
MOLYBDENUM ISOTOPES
NICKEL ISOTOPES
NIOBIUM ISOTOPES
ORGANIC COMPOUNDS
OSMIUM ISOTOPES
PALLADIUM ISOTOPES
PLATINUM ISOTOPES
PROCESSING
RADIOISOTOPES
RHENIUM ISOTOPES
RUTHENIUM ISOTOPES
SYNTHESIS
TANTALUM ISOTOPES
TECHNETIUM ISOTOPES
TELLURIUM COMPLEXES
TIN COMPLEXES
TUNGSTEN ISOTOPES
ZINC COMPLEXES