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Title: Metal-isonitrile adducts for preparing radionuclide complexes for labelling and imaging agents

Abstract

A method for preparing a coordination complex of an isonitrile ligand and radionuclide such as Tc, Ru, Co, Pt, Fe, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Pd, Nb and Ta is disclosed. The method comprises preparing a soluble metal adduct of said isonitrile ligand by admixing said ligand with a salt of a displaceable metal having a complete d-electron shell selected from the group consisting of Zn, Ga, Cd, In, Sn, Hg, Tl, Pb and Bi to form a soluble metal-isonitrile salt, and admixing said metal isonitrile salt with a salt comprising said radioactive metal in a suitable solvent to displace said displaceable metal with the radioactive metal thereby forming said coordination. The complex is useful as a diagnostic agent for labelling liposomes or vesicles, and selected living cells containing lipid membranes, such as blood clots, myocardial tissue, gall bladder tissue, etc.

Inventors:
 [1];  [2];  [3]
  1. Newton Centre, MA
  2. Needham, MA
  3. Westchester, PA
Publication Date:
Research Org.:
Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)
OSTI Identifier:
866429
Patent Number(s):
US 4707544
Assignee:
President and Fellows of Harvard College (Cambridge, MA); Massachusetts Institute of Technology (Cambridge, MA)
DOE Contract Number:  
AC02-81EV10649
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
metal-isonitrile; adducts; preparing; radionuclide; complexes; labelling; imaging; agents; method; coordination; complex; isonitrile; ligand; tc; ru; mn; pd; nb; disclosed; comprises; soluble; metal; adduct; admixing; salt; displaceable; complete; d-electron; shell; selected; consisting; zn; cd; hg; pb; form; comprising; radioactive; suitable; solvent; displace; forming; useful; diagnostic; agent; liposomes; vesicles; living; cells; containing; lipid; membranes; blood; clots; myocardial; tissue; gall; bladder; etc; radionuclide complexes; radioactive metal; living cells; isonitrile ligand; imaging agents; active metal; suitable solvent; method comprises; soluble metal; cells containing; method comprise; coordination complex; imaging agent; comprises preparing; myocardial tissue; lipid membranes; cells contain; diagnostic agent; /424/999/987/

Citation Formats

Jones, Alun G, Davison, Alan, and Abrams, Michael J. Metal-isonitrile adducts for preparing radionuclide complexes for labelling and imaging agents. United States: N. p., 1987. Web.
Jones, Alun G, Davison, Alan, & Abrams, Michael J. Metal-isonitrile adducts for preparing radionuclide complexes for labelling and imaging agents. United States.
Jones, Alun G, Davison, Alan, and Abrams, Michael J. 1987. "Metal-isonitrile adducts for preparing radionuclide complexes for labelling and imaging agents". United States. https://www.osti.gov/servlets/purl/866429.
@article{osti_866429,
title = {Metal-isonitrile adducts for preparing radionuclide complexes for labelling and imaging agents},
author = {Jones, Alun G and Davison, Alan and Abrams, Michael J},
abstractNote = {A method for preparing a coordination complex of an isonitrile ligand and radionuclide such as Tc, Ru, Co, Pt, Fe, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Pd, Nb and Ta is disclosed. The method comprises preparing a soluble metal adduct of said isonitrile ligand by admixing said ligand with a salt of a displaceable metal having a complete d-electron shell selected from the group consisting of Zn, Ga, Cd, In, Sn, Hg, Tl, Pb and Bi to form a soluble metal-isonitrile salt, and admixing said metal isonitrile salt with a salt comprising said radioactive metal in a suitable solvent to displace said displaceable metal with the radioactive metal thereby forming said coordination. The complex is useful as a diagnostic agent for labelling liposomes or vesicles, and selected living cells containing lipid membranes, such as blood clots, myocardial tissue, gall bladder tissue, etc.},
doi = {},
url = {https://www.osti.gov/biblio/866429}, journal = {},
number = ,
volume = ,
place = {United States},
year = {1987},
month = {1}
}