Life-shortening and carcinogenesis in mice irradiated neonatally with x rays
Journal Article
·
· Radiat. Res.; (United States)
- National Inst. of Radiological Sciences, Chiba, Japan
The characteristics of life-shortening and carcinogenesis were investigated in x-irradiated neonatal B6WFr mice. Animals were irradiated with 24 hr after birth and allowed to complete their normal life span. Mean life span was shortened linearly with doses at a rate of 9.1% per 100 R for females and 9.8% for males. The spectrum of neoplastic diseases was apparently modulated by x irradiation, showing neonatal B6WFr mice to be highly susceptible to the induction of thymic lymphoma, liver tumor, and pituitary tumor. The dose-response relationship for thymice lymphoma could be described by a linear-quadratic model, and linearity could be rejected. Thymic lymphoma developed after a short latent period, resulting in death between 100 and 450 days of age. Liver and pituitary tumors increased with increasing dose up to 400 R and decreased thereafter. The latent period for liver tumor development was apparently shortened with increasing doses. Pituitary tumor developed in excess only in females after a long latent period.
- OSTI ID:
- 5887266
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 88:2; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOGENESIS
DIGESTIVE SYSTEM
DISEASES
DOSES
ELECTROMAGNETIC RADIATION
ENDOCRINE GLANDS
GLANDS
IONIZING RADIATIONS
LIFE SPAN
LIVER
LYMPHATIC SYSTEM
LYMPHOMAS
MAMMALS
MICE
MORTALITY
NEONATES
NEOPLASMS
ORGANS
PATHOGENESIS
PITUITARY GLAND
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RODENTS
THYMUS
VERTEBRATES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOGENESIS
DIGESTIVE SYSTEM
DISEASES
DOSES
ELECTROMAGNETIC RADIATION
ENDOCRINE GLANDS
GLANDS
IONIZING RADIATIONS
LIFE SPAN
LIVER
LYMPHATIC SYSTEM
LYMPHOMAS
MAMMALS
MICE
MORTALITY
NEONATES
NEOPLASMS
ORGANS
PATHOGENESIS
PITUITARY GLAND
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RODENTS
THYMUS
VERTEBRATES
X RADIATION