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Improved survival of newborns receiving leukocyte transfusions for sepsis

Journal Article · · Pediatrics; (United States)
OSTI ID:5886043
; ; ; ; ; ; ;
To determine the role of polymorphonuclear (PMN) leukocyte transfusions in neonates with sepsis, 23 consecutive newborns were prospectively randomly selected during an 18-month period in a treatment plan to receive polymorphonuclear leukocyte transfusions with supportive care or supportive care alone. Thirteen neonates received transfusions every 12 hours for a total of five transfusions. Each transfusion consisting of 15 mL/kg of polymorphonuclear leukocytes was subjected to 1,500 rads of radiation. The polymorphonuclear leukocytes were obtained by continuous-flow centrifugation leukapheresis and contained 0.5 to 1.0 X 10(9) granulocytes per 15 mL with less than 10% lymphocytes. Positive findings on blood cultures were obtained in 14/23 patients and seven were randomly selected for each treatment group. Absolute granulocyte counts were less than 1,500/microL in 13 patients but tibial bone marrow examinations revealed that the neutrophil supply pool was depleted in only three patients. The survival was significantly greater in the treatment group compared with the group that did not receive transfusions.
Research Organization:
Univ. of California, Irvine
OSTI ID:
5886043
Journal Information:
Pediatrics; (United States), Journal Name: Pediatrics; (United States) Vol. 74:5; ISSN PEDIA
Country of Publication:
United States
Language:
English

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Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
BACTERIAL DISEASES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
DISEASES
HEMATOPOIETIC SYSTEM
INFECTIOUS DISEASES
LEUKOCYTES
MATERIALS
NEONATES
ORGANS
RADIATION EFFECTS
SURVIVAL CURVES
THERAPY
TISSUES
TRANSFUSIONS