Improvement in regional ventilation and perfusion after radiotherapy for unresectable carcinoma of the bronchus. [/sup 81m/Kr + /sup 99m/Tc scanning to assess post radiotherapy lung function]

Journal Article · Wed Aug 01 00:00:00 EDT 1979 · Am. J. Roentgenol.; (United States)

DOI:https://doi.org/10.2214/ajr.133.2.191· OSTI ID:5883684

Fazio, F ^[1]; Pratt, T A; McKenzie, C G; Steiner, R E

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1. Hammersmith Hospital, London, England

Ventilation/perfusion scans were obtained in 45 patients with unresectable carcinoma of the bronchus. Of these 45 patients, 35 were reinvestigated shortly after radiotherapy and 17 of them had additional later follow-up studies. Both ventilation and perfusion were always abnormal in the lung affected by the tumor; perfusion was usually more impaired than ventilation. These abnormalities were difficult to detect or to evaluate from the standard chest radiograph. After radiotherapy, ventilation improved in 83% and perfusion in 86% of the patients. This improvement was associated with amelioration of breathlessness, which improved in 74% of the patients. Slow but progressive deterioration of regional ventilation and perfusion were subsequently observed. This was often associated with the development of radiation fibrosis. Spirometric measurements (VC, FEV/sub 1/) were moderately impaired at the initial assessment (83% and 66% of predicted, respectively), probably due to coexisting chronic airway obstruction, and did not show significant changes after radiotherapy or during the follow-up. Radionuclide studies of regional perfusion and ventilation proved more sensitive and more specific than tests of overall lung function for the functional assessment and follow-up of patients with unresectable carcinoma of the bronchus.

• OSTI ID: 5883684
• Journal Information: Am. J. Roentgenol.; (United States), Journal Name: Am. J. Roentgenol.; (United States) Vol. 133:2; ISSN AJROA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACCELERATORS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
BRONCHI
CARCINOMAS
CHEST
COBALT 60
COBALT ISOTOPES
COUNTING TECHNIQUES
DELAYED RADIATION EFFECTS
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
DYNAMIC FUNCTION STUDIES
ELECTROMAGNETIC RADIATION
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
EXTERNAL IRRADIATION
FIBROSIS
FRACTIONATED IRRADIATION
GAMMA RADIATION
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KRYPTON 81
KRYPTON ISOTOPES
LABELLED COMPOUNDS
LINEAR ACCELERATORS
LUNGS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANS
PARTIAL BODY IRRADIATION
PATHOLOGICAL CHANGES
PATIENTS
RADIATION EFFECTS
RADIATIONS
RADIOACTIVE MATERIALS
RADIOINDUCTION
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
RADIOPHARMACEUTICALS
RADIOTHERAPY
RESPIRATORY SYSTEM
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
SIDE EFFECTS
TECHNETIUM 99
TECHNETIUM ISOTOPES
THERAPY
YEARS LIVING RADIOISOTOPES