Clinical trial of razoxane and radiotherapy for inoperable carcinoma of the bronchus
Conference
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
OSTI ID:5275594
- Middlesex Hospital, London, England
One hundred thirteen patients with inoperable carcinoma of the bronchus were randomly allocated to receive either radiotherapy or radiotherapy plus razoxane. They were stratified according to histology and analyzed according to whether they had oat-cell or non oat-cell carcinomas and whether they tolerated only 1 course (3000 rad) or 2 courses (6000 rad) of radiotherapy. Of the patients who had 2 courses of radiotherapy, only 7% developed leukopenia and the same percentage developed severe esophagitis; but of those who had the combined treatment, 32% developed leukopenia and the same percentage developed severe esophagitis. Although the median survival time was greater in those who received the combined treatment in both one treatment and two treatment groups, neither achieved statistical significance. Sixty-four percent of patients who had two treatments (i.e., 6000 rad plus razoxane) survived 12 months; this compares favorably with most other published clinical trials of inoperable carcinoma of the bronchus.
- OSTI ID:
- 5275594
- Conference Information:
- Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 5:9
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRONCHI
CARCINOMAS
DIGESTIVE SYSTEM
DISEASES
DRUGS
ESOPHAGUS
FRACTIONATED IRRADIATION
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
INFLAMMATION
IRRADIATION
LEUKOPENIA
LOCAL IRRADIATION
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
RESPIRATORY SYSTEM
SIDE EFFECTS
SURVIVAL TIME
SYMPTOMS
THERAPY
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRONCHI
CARCINOMAS
DIGESTIVE SYSTEM
DISEASES
DRUGS
ESOPHAGUS
FRACTIONATED IRRADIATION
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
INFLAMMATION
IRRADIATION
LEUKOPENIA
LOCAL IRRADIATION
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
RESPIRATORY SYSTEM
SIDE EFFECTS
SURVIVAL TIME
SYMPTOMS
THERAPY