Pathways of hepatic glycogen formation in humans following ingestion of a glucose load in the fed state
The relative contributions of the direct and the indirect pathways to hepatic glycogen formation following a glucose load given to humans four hours after a substantial breakfast have been examined. Glucose loads labeled with (6-(/sup 14/)C)glucose were given to six healthy volunteers along with diflunisal (1 g) or acetaminophen (1.5 g), drugs excreted in urine as glucuronides. Distribution of /sup 14/C in the glucose unit of the glucuronide was taken as a measure of the extent to which glucose was deposited directly in liver glycogen (ie, glucose----glucose-6-phosphate----glycogen) rather than indirectly (ie, glucose----C3-compound----glucose-6-phosphate----glycogen). The maximum contribution to glycogen formation by the direct pathway was estimated to be 77% +/- 4%, which is somewhat higher than previous estimates in humans fasted overnight (65% +/- 1%, P less than 0.05). Thus, the indirect pathway of liver glycogen formation following a glucose load is operative in both the overnight fasted and the fed state, although its contribution may be somewhat less in the fed state.
- Research Organization:
- Karolinska Institute (Sweden)
- OSTI ID:
- 5878946
- Journal Information:
- Metab., Clin. Exp.; (United States), Journal Name: Metab., Clin. Exp.; (United States) Vol. 38:6; ISSN METAA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
ANIMALS
BIOLOGICAL PATHWAYS
BIOSYNTHESIS
BODY
CARBOHYDRATES
CARBON 14 COMPOUNDS
DIGESTIVE SYSTEM
FOOD
GLANDS
GLUCOSE
GLYCOGEN
HEXOSES
INGESTION
INTAKE
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIVER
MAMMALS
MAN
METABOLISM
MONOSACCHARIDES
ORGANIC COMPOUNDS
ORGANS
POLYSACCHARIDES
PRIMATES
SACCHARIDES
SYNTHESIS
TRACER TECHNIQUES
VERTEBRATES