Deposition of Crocidolite asbestos and glass microfibers inhaled by the beagle dog
The respiratory tract deposition of neutron activated Crocidolite asbestos and glass microfibers was determined in two groups of four Beagle dogs. The dogs were given 60-minute, nose-only inhalation exposures to an aerosol of either asbestos or glass fibers. The radioactivity in tissues and excreta four days after exposure was used to determine the fraction of inhaled fibers deposited in the upper respiratory tract and the deep lung. The activity median aerodynamic diameter (AMAD), count median diameter (CMD) and count median length (CML) were determined from fibers sampled during exposure. Crocidolite asbestos fibers had an AMAD of 1.8 ..mu..m, a CMD of 0.25 ..mu..m and a CML < 5 ..mu..m. The fraction of inhaled mass deposited in deep lung was 13-19%, while total deposition in the respiratory tract was 54-72%. Glass microfibers had an AMAD of 2.5 ..mu..m, a CMD of 0.15 ..mu..m and a CML of 5.4 ..mu... Five to 17% of the mass of glass fiber was deposited in the deep lung; total respiratory tract deposition was 45-64%. The deposition patterns were similar for these small asbestos and glass fibers inhaled by dogs and in good agreement with previous predictions made for man. 24 references, 4 figures, 5 tables.
- Research Organization:
- Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM
- DOE Contract Number:
- AC04-76EV01013
- OSTI ID:
- 5876580
- Journal Information:
- Am. Ind. Hyg. Assoc. J.; (United States), Journal Name: Am. Ind. Hyg. Assoc. J.; (United States) Vol. 44:3; ISSN AIHAA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Retention of monodisperse or polydisperse aluminosilicate particles inhaled by dogs, rats, and mice
Clearance and dimensional changes of crocidolite asbestos fibers isolated from lungs of rats following short-term exposure
Related Subjects
400101 -- Activation
Nuclear Reaction
Radiometric & Radiochemical Procedures
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTIVATION ANALYSIS
AEROSOLS
ANIMALS
ASBESTOS
BARYON REACTIONS
BIOLOGICAL MODELS
BODY
CHEMICAL ANALYSIS
CLEARANCE
COLLOIDS
DATA
DISPERSIONS
DOGS
DYNAMIC FUNCTION STUDIES
EXCRETION
EXPERIMENTAL DATA
FIBERS
GLASS
HADRON REACTIONS
INFORMATION
INHALATION
INTAKE
LUNGS
MAMMALS
NEUTRON REACTIONS
NUCLEAR REACTIONS
NUCLEON REACTIONS
NUMERICAL DATA
ORGANS
PARTICLE SIZE
RESPIRATORY SYSTEM
RETENTION
SIZE
SOLS
VERTEBRATES